Diagn Pathol. 2013 Jun 21;8:103. doi: 10.1186/1746-1596-8-103.
Epithelioid hemangioendothelioma is a relatively uncommon lesion usually presenting in soft tissues. The occurrence in the mediastinum is exceptional rare. Histologically, this tumor is characterized by epithelioid cells with intracytoplasmic vacuoles in a hyalinized or mucinous stroma. Occasionally, spindle cells or osteoclast-like giant cells can be observed. Herein, we present a case of epithelioid hemangioendothelioma in a 38 year-old Chinese male. The tumor was predominantly composed of abundant spindle cells with marked atypia and scattered osteoclast-like giant cells reminiscent of malignant fibrous histiocytoma. The unusual histological appearance can pose a great diagnostic challenge. It may be easily misdiagnosed, especially if the specimen is limited or from fine-needle aspiration.
上皮样血管内皮细胞瘤是一种相对少见的病变，通常发生于软组织中。发生于纵隔的情况极为罕见。组织学上，该肿瘤的特征是在玻璃样或黏液样基质中有上皮样细胞和细胞内空泡。偶尔可见梭形细胞或破骨样巨细胞。本文报道了 1 例 38 岁的中国男性上皮样血管内皮细胞瘤。肿瘤主要由丰富的梭形细胞组成，具有明显的异型性，散在分布破骨样巨细胞，类似于恶性纤维组织细胞瘤。这种不常见的组织学表现可能会带来很大的诊断挑战。如果标本有限或来自细针穿刺，很容易误诊，尤其是如此。
