Gong Zhi-Hua, Yan Lv-Jun, Sun Jian-Guo
Department of Oncology, Cancer Institute of People's Liberation Army, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China.
Oncol Lett. 2014 Oct;8(4):1856-1858. doi: 10.3892/ol.2014.2421. Epub 2014 Aug 5.
Superior vena cava (SVC) syndrome results from clear cell renal cell carcinoma and is a challenge in clinical practice due to its pathological complexity and a lack of research data. The current study presents a 49-year-old female with symptoms of exertional dyspnea and increased fatigue, which had persisted for 15 months, as well as bilateral edema in the lower limbs for two days. A transesophageal echocardiogram demonstrated a right atrial mass originating from the inferior vena cava (IVC; size, 14×8 cm) that caused a tricuspid inflow obstruction. Following a partial resection of the thrombus, a clear cell renal cell carcinoma was identified by histological examination. The patient received intensity-modulated radiation therapy following refusal of other therapeutic methods. The eleven-month follow-up indicated that the tumor on the kidney and IVC was stable. Intensity-modulated radiation therapy may be beneficial to patients with clear cell renal cell carcinoma and SVC syndrome. However, additional studies are required to obtain further data regarding the treatment of this syndrome.
上腔静脉（SVC）综合征由透明细胞肾细胞癌引起，因其病理复杂性和缺乏研究数据，在临床实践中是一项挑战。本研究报告了一名49岁女性，有劳力性呼吸困难和疲劳加重症状，持续15个月，以及双下肢水肿两天。经食管超声心动图显示右心房有一肿块，起源于下腔静脉（IVC；大小为14×8 cm），导致三尖瓣流入道梗阻。在部分切除血栓后，组织学检查确诊为透明细胞肾细胞癌。在拒绝其他治疗方法后，该患者接受了调强放射治疗。11个月的随访表明，肾脏和IVC上的肿瘤稳定。调强放射治疗可能对透明细胞肾细胞癌和SVC综合征患者有益。然而，需要更多研究以获取关于该综合征治疗的进一步数据。
