Jia Yong-Guang, Zhu X X
Département de Chimie, Université de Montréal , C.P. 6128, Succursale Centre-ville, Montréal, Quebec H3C 3J7, Canada.
Langmuir. 2014 Oct 7;30(39):11770-5. doi: 10.1021/la5030873. Epub 2014 Sep 22.
Copolymers of N-alkylacrylamides and methacrylate bearing cholic acid pendant groups were synthesized via radical polymerization. The cholic acid pendant groups of such copolymers can form complexes with β-cyclodextrin, and the effect of complexation on their thermoresponsive properties was studied. The phase transition temperatures (transition from hydrophilic to hydrophobic state) of the copolymers gradually increase with the addition of β-cyclodextrin, due to the complexation of the cholic acid guest with the β-cyclodextrin host. The increase of the phase transition temperature may be reversed by the addition of a competing guest molecule, potassium 1-adamantylcarboxylate. The host-guest complexation provides a straightforward way to vary the thermoresponsive properties of such copolymers.
通过自由基聚合反应合成了带有胆酸侧基的N-烷基丙烯酰胺与甲基丙烯酸酯的共聚物。这类共聚物的胆酸侧基可与β-环糊精形成络合物，并研究了络合作用对其热响应性能的影响。由于胆酸客体与β-环糊精主体的络合作用，共聚物的相转变温度（从亲水性状态转变为疏水性状态）随着β-环糊精的加入而逐渐升高。加入竞争客体分子1-金刚烷基甲酸钾可使相转变温度的升高发生逆转。主客体络合作用为改变这类共聚物的热响应性能提供了一种直接的方法。
