鞘内注射阿片类药物在急性疼痛管理中的作用。

The role of intrathecal opiates in the management of acute pain.

作者信息

Naulty J S

机构信息

Department of Anesthesia, George Washington University, Washington, D.C.

出版信息

Clin J Pain. 1989;5 Suppl 1:S16-27. doi: 10.1097/00002508-198903001-00006.

DOI:10.1097/00002508-198903001-00006

PMID:2520428

Abstract

This article reviews the literature and describes clinical methods of providing analgesia for acute pain using epidural and intrathecal (spinal) opiates. The mechanism of action of these drugs, their basic pharmacology and spinal pharmacodynamics, and useful drugs and dosages are presented. The side effects of these drugs when administered by injection and possible ways to diminish their incidence and severity are discussed. A clinical protocol for the dosage and selection of these drugs is included.

摘要

本文回顾了相关文献，并描述了使用硬膜外和鞘内（脊髓）阿片类药物为急性疼痛提供镇痛的临床方法。介绍了这些药物的作用机制、基本药理学和脊髓药效学，以及有用的药物和剂量。讨论了这些药物注射给药时的副作用以及降低其发生率和严重程度的可能方法。文中还包括了这些药物剂量和选择的临床方案。