Cherbuin Nicolas, Sargent-Cox Kerry, Easteal Simon, Sachdev Perminder, Anstey Kaarin J
Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia.
Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia.
Am J Geriatr Psychiatry. 2015 May;23(5):446-55. doi: 10.1016/j.jagp.2014.07.009. Epub 2014 Aug 7.
To investigate whether subjective memory decline (SMD) in cognitively healthy individuals is associated with hippocampal atrophy.
Multiple regression analyses assessing the relationship between hippocampal atrophy over 4 years and SMD at baseline and follow-up in 305 cognitively healthy individuals aged 60-64 years free from dementia, mild cognitive impairment, and other neurological disorders.
SMD at baseline was not a significant predictor of hippocampal atrophy. However, SMD at follow-up was associated with greater hippocampal atrophy. Associations were reduced but remained significant after controlling for anxiety and depression symptomatology.
Hippocampal atrophy was associated with incident/persisting SMD and this association was not, or only partly, explained by anxiety and depression symptomatology. These results are consistent with a biological origin to subjective memory decline. SMD should be included in screening and neuropsychological batteries.
探讨认知健康个体的主观记忆减退（SMD）是否与海马萎缩有关。
对305名年龄在60 - 64岁、无痴呆、轻度认知障碍及其他神经系统疾病的认知健康个体进行多元回归分析，评估4年中海马萎缩与基线及随访时SMD之间的关系。
基线时的SMD不是海马萎缩的显著预测因素。然而，随访时的SMD与更大程度的海马萎缩有关。在控制焦虑和抑郁症状后，这种关联有所减弱但仍显著。
海马萎缩与新发/持续存在的SMD有关，且这种关联并非完全由焦虑和抑郁症状解释，或仅部分由其解释。这些结果与主观记忆减退的生物学起源一致。SMD应纳入筛查和神经心理测试组合中。
Zotero 插件