Akin Elvan, Krüger Ulrich, Braun Peter, Stroh Erika, Janicke Ilse, Rezwanian Reza, Akin Ibrahim, Schöls Wolfgang H
Herzzentrum Duisburg, Akademisches Lehrkrankenhaus, Heinrich-Heine-Universität Düsseldorf, Duisburg, Deutschland.
Wien Med Wochenschr. 2014 Sep;164(17-18):372-6. doi: 10.1007/s10354-014-0303-z. Epub 2014 Sep 10.
Dyspnoe is a symptom with a huge differential diagnostic spectrum. According to patients hemodynamic, acute forms can be caused by myocardial infarction, pulmonary embolism, pulmonary edema and heart rhythm disturbances while chronic forms can be caused by restrictive myocardial and pericardial diseases, hematooncological diseases, orthopedic deformations and chronic pulmonary diseases. The platypnea-orthodeoxia syndrome with underlying interatrial connection is a rare cause and need a special diagnostic work-up.
A 62-year old male patient with previously known pneumectomy on right side due to underlying cancer presented with a 6-months history of increasing dyspnoe (NYHA III) on exertion and upright position. The physical examination just revealed a lack of ventilation on right side. The saturation drops from 97% in supine position to 68% in upright position. Transesophageal echocardiography revealed a compressed right atrium with a persisted foramen ovale (PFO) and atrial septal aneurysm resulting in a right-left shunt. After completing diagnostic work-up and excluding other possible causes for dyspnoe an interventional closure of interatrial connection was performed. Subsequently the symptoms of the patients resolved (NYHA I).
The Platypnea-Orthodeoxia-Syndrome isa rare cause of dyspoe. The diagnosis can be made by echocardiography. Medical treatment of such disease is of less success, thus a closure of interatrial connection is recommended.
呼吸困难是一种具有广泛鉴别诊断范围的症状。根据患者的血流动力学情况,急性形式可由心肌梗死、肺栓塞、肺水肿和心律失常引起,而慢性形式可由限制性心肌和心包疾病、血液肿瘤疾病、骨科畸形和慢性肺部疾病引起。伴有潜在心房连接的平卧呼吸-直立性低氧血症综合征是一种罕见病因,需要特殊的诊断检查。
一名62岁男性患者,既往因潜在癌症行右侧肺切除术,出现劳力性和直立位时呼吸困难加重6个月病史(纽约心脏协会心功能分级III级)。体格检查仅发现右侧通气不足。饱和度从仰卧位时的97%降至直立位时的68%。经食管超声心动图显示右心房受压,伴有持续存在的卵圆孔未闭(PFO)和房间隔瘤,导致右向左分流。在完成诊断检查并排除其他可能的呼吸困难原因后,对心房连接进行了介入封堵。随后患者症状缓解(纽约心脏协会心功能分级I级)。
平卧呼吸-直立性低氧血症综合征是呼吸困难的罕见病因。可通过超声心动图进行诊断。此类疾病的药物治疗效果欠佳,因此建议封堵心房连接。