Wang Jun-Feng, Deng Yi-Hui, Yang Sheng-Hui, Liu Yan-Qun, Wang Yue-Hu, Pan Wei-Wei, Zhou Xiao-Jiang
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, PR China.
College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, PR China; Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha 410208, PR China.
Bioorg Med Chem Lett. 2014 Oct 1;24(19):4667-4671. doi: 10.1016/j.bmcl.2014.08.042. Epub 2014 Aug 27.
Investigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C-H (1-6) bearing an unusual α,β-unsaturated ketone group. The new structures of 1-6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1-6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1μM, and 13.8 to 74.3μM.
