State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Bioorg Med Chem Lett. 2011 Jan 1;21(1):373-6. doi: 10.1016/j.bmcl.2010.10.135. Epub 2010 Oct 31.
Two new dimeric lignans, zanthpodocarpins A (1) and B (2), and five known lignans, eudesmin (3), (1R,2R,5R,6S)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (4), dimethoxysamin (5), rel-(1R,5R,6S)-6-(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo[3.3.0]octan-2-one (6), and magnone A (7), were isolated from the barks of Zanthoxylum podocarpum. Their structures were identified by using spectroscopic methods. Compounds 1 and 2 are rare dilignans bearing an unusual α,β-unsaturated ketone group from a natural source. Bioassay showed that compounds 1 and 2 could inhibit nitric oxide (NO) production in LPS stimulated RAW 264.7 cells with IC(50) values of 5.31 μM and 12.15 μM, respectively.
从飞龙掌血（Zanthoxylum podocarpum）树皮中分离得到两个新的二聚木脂素，黄樟素 A（1）和 B（2），以及五个已知的木脂素，桉叶素（3），（1R,2R,5R,6S）-2-（3,4-二甲氧基苯基）-6-（3,4-二羟基苯基）-3,7-二氧杂双环[3.3.0]辛烷（4），二甲氧基氨（5），（1R,5R,6S）-6-（4-羟基-3-甲氧基苯基）-3,7-二氧杂双环[3.3.0]辛烷-2-酮（6）和木兰酮 A（7）。通过光谱方法鉴定了它们的结构。化合物 1 和 2 是从天然来源中罕见的具有不寻常的α,β-不饱和酮基的双木脂素。生物测定表明，化合物 1 和 2 能够抑制 LPS 刺激的 RAW 264.7 细胞中一氧化氮（NO）的产生，其 IC50 值分别为 5.31 μM 和 12.15 μM。
