Xu Ping, Xu Cheng-Fu, Wan Xing-Yong, Yu Chao-Hui, Shen Chao, Chen Peng, Xu Gen-Yun, Li You-Ming
Ping Xu, Cheng-Fu Xu, Xing-Yong Wan, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
World J Gastroenterol. 2014 Sep 7;20(33):11865-70. doi: 10.3748/wjg.v20.i33.11865.
To investigate the association between serum alpha-fetoprotein (AFP) levels and fatty liver disease (FLD) in a Chinese population.
A cross-sectional study was performed among subjects who presented for a health examination at the First Affiliated Hospital, College of Medicine, Zhejiang University in 2013. FLD was diagnosed based on an ultrasonography examination. Serum AFP levels were measured with a chemiluminescence immunoassay.
Of the 9800 subjects enrolled, 2601 were diagnosed with FLD. Subjects with FLD had higher serum AFP levels than those without the disease. Subjects with high serum AFP levels had a higher prevalence of FLD, metabolic syndrome, and its components. Univariate logistic analysis showed that elevated serum AFP levels were associated with an increased risk of FLD (OR = 1.057, 95%CI: 1.031-1.084). However, after adjusting for covariates, AFP no longer remained significantly associated with the risk factors for FLD.
Our results suggest that serum AFP levels are significantly associated with FLD and that AFP acts as a cofactor, but not as an independent factor, for FLD.
研究中国人群中血清甲胎蛋白（AFP）水平与脂肪肝疾病（FLD）之间的关联。
于2013年对在浙江大学医学院附属第一医院进行健康体检的受试者开展了一项横断面研究。基于超声检查诊断FLD。采用化学发光免疫分析法测定血清AFP水平。
在纳入的9800名受试者中，2601人被诊断为FLD。患有FLD的受试者血清AFP水平高于未患该疾病的受试者。血清AFP水平高的受试者患FLD、代谢综合征及其组分的患病率更高。单因素逻辑回归分析显示，血清AFP水平升高与FLD风险增加相关（比值比=1.057，95%置信区间：1.031-1.084）。然而，在对协变量进行校正后，AFP与FLD的风险因素不再显著相关。
我们的结果表明，血清AFP水平与FLD显著相关，且AFP作为FLD的一个辅助因素，但并非独立因素。
