Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.
J Hum Hypertens. 2023 Jun;37(6):496-501. doi: 10.1038/s41371-022-00694-w. Epub 2022 May 26.
Previous studies demonstrated inconsistent results regarding the association between liver function and hypertension. In addition, large cohort follow-up studies are lacking. Therefore, this longitudinal study aimed to investigate the association between liver function and incident hypertension using data from the Taiwan Biobank (TWB). We evaluated liver biomarkers, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, alpha-fetoprotein (AFP), total bilirubin, and gamma-glutamyl transferase (GGT) in this study. A total of 21,293 participants without hypertension at baseline were analyzed. During the mean 3.9-year follow-up, 3002 participants developed hypertension (defined as incident hypertension). Multivariable analysis revealed that high AST (odds ratio [OR], 1.004; 95% confidence interval [CI], 1.001-1.007; p = 0.014), high ALT (OR, 1.004; 95% CI, 1.002-1.006; p < 0.001), high albumin (OR, 1.897; 95% CI, 1.573-2.286; p < 0.001), and high GGT (OR, 1.004; 95% CI, 1.003-1.005; p < 0.001) were significantly associated with incident hypertension in all study participants. In subgroup analysis of the participants with an ALT level ≤2 times the normal limit (80 u/l) (n = 20,983), multivariable analysis demonstrated that high ALT (OR, 1.009; 95% CI, 1.005-1.012; p < 0.001) and high GGT (OR, 1.005; 95% CI, 1.003-1.006; p < 0.001) were significantly associated with incident hypertension. In conclusion, we found that elevated AST, ALT, albumin, and GGT were associated with incident hypertension in a large Taiwanese cohort. A greater understanding of potential risk factors for hypertension may help to reduce the burden of hypertension in this Taiwanese population.
先前的研究表明，肝功能与高血压之间的关联结果不一致。此外，缺乏大型队列随访研究。因此，本纵向研究旨在使用来自台湾生物银行（TWB）的数据来探讨肝功能与高血压的发生之间的关联。我们在本研究中评估了肝功能标志物，包括天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、白蛋白、甲胎蛋白（AFP）、总胆红素和谷氨酰转移酶（GGT）。共分析了 21293 名基线时无高血压的参与者。在平均 3.9 年的随访期间，有 3002 名参与者发生了高血压（定义为高血压事件）。多变量分析显示，AST 升高（比值比 [OR]，1.004；95%置信区间 [CI]，1.001-1.007；p=0.014）、ALT 升高（OR，1.004；95%CI，1.002-1.006；p<0.001）、白蛋白升高（OR，1.897；95%CI，1.573-2.286；p<0.001）和 GGT 升高（OR，1.004；95%CI，1.003-1.005；p<0.001）与所有研究参与者的高血压事件显著相关。在 ALT 水平≤2 倍正常值（80u/l）（n=20983）的参与者亚组分析中，多变量分析显示，ALT 升高（OR，1.009；95%CI，1.005-1.012；p<0.001）和 GGT 升高（OR，1.005；95%CI，1.003-1.006；p<0.001）与高血压事件显著相关。综上所述，我们发现，在一个大型台湾队列中，AST、ALT、白蛋白和 GGT 的升高与高血压事件有关。对高血压潜在危险因素的进一步了解可能有助于降低该台湾人群的高血压负担。
