青少年社会隔离会影响成年大鼠的认知功能。
Adolescent social isolation influences cognitive function in adult rats.
机构信息
Department of Psychology, Peking University, Beijing 100871, China.
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
出版信息
Neural Regen Res. 2013 Apr 15;8(11):1025-30. doi: 10.3969/j.issn.1673-5374.2013.11.008.
Adolescence is a critical period for neurodevelopment. Evidence from animal studies suggests that isolated rearing can exert negative effects on behavioral and brain development. The present study aimed to investigate the effects of adolescent social isolation on latent inhibition and brain-derived neurotrophic factor levels in the forebrain of adult rats. Male Wistar rats were randomly divided into adolescent isolation (isolated housing, 38-51 days of age) and social groups. Latent inhibition was tested at adulthood. Brain-derived neurotrophic factor levels were measured in the medial prefrontal cortex and nucleus accumbens by an enzyme-linked immunosorbent assay. Adolescent social isolation impaired latent inhibition and increased brain-derived neurotrophic factor levels in the medial prefrontal cortex of young adult rats. These data suggest that adolescent social isolation has a profound effect on cognitive function and neurotrophin levels in adult rats and may be used as an animal model of neurodevelopmental disorders.
青春期是神经发育的关键时期。动物研究的证据表明，隔离饲养会对行为和大脑发育产生负面影响。本研究旨在探讨青春期社交隔离对成年大鼠前额叶中潜伏抑制和脑源性神经营养因子水平的影响。雄性 Wistar 大鼠随机分为青春期隔离（隔离饲养，38-51 日龄）和社交组。成年后进行潜伏抑制测试。通过酶联免疫吸附试验测量内侧前额叶皮层和伏隔核中的脑源性神经营养因子水平。青春期社交隔离会损害年轻成年大鼠的潜伏抑制，并增加内侧前额叶皮层中的脑源性神经营养因子水平。这些数据表明，青春期社交隔离对成年大鼠的认知功能和神经营养因子水平有深远影响，可作为神经发育障碍的动物模型。
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