Institute of Public Hygiene, School of Nursing, Henan University, Kaifeng 475004, Henan Province, China.
Department of Anatomy, Medical College of Henan University, Kaifeng 475004, Henan Province, China.
Neural Regen Res. 2013 Jun 15;8(17):1560-7. doi: 10.3969/j.issn.1673-5374.2013.17.003.
Studies have shown that there are strong interactions between gustatory and visceral sensations in the central nervous system when rats ingest sweet foods or solutions. To investigate the role of the subdiaphragmatic vagi in transmitting general visceral information during the process of drinking sweet-tasting solutions, we examined the effects of subdiaphragmatic vagotomy on the intake of 0.5 mol/L sucrose, 0.005 mol/L saccharin or distilled water over the course of 1 hour in rats deprived of water. Results showed no significant difference in consumption of these three solutions in vagotomized rats. However, rats in the sham-surgery group drank more saccharin solution than sucrose solution or distilled water. Moreover, the intake of distilled water was similar between vagotomized rats and sham-surgery group rats, but significantly less sucrose and saccharin were consumed by vagotomized rats compared with rats in the sham-surgery group. These findings indicate that subdiaphragmatic vagotomy reduces intake of sweet-tasting solution in rats, and suggest that vagal and extravagal inputs play a balanced role in the control of the intake of sweet-tasting solutions. They also suggest that subdiaphragmatic vagotomy eliminates the difference in hedonic perception induced by sweet-tasting solutions compared with distilled water.
研究表明，当老鼠摄入甜食或溶液时，味觉和内脏感觉在中枢神经系统中存在强烈的相互作用。为了研究膈下迷走神经在饮用甜味溶液过程中传递一般内脏信息的作用，我们观察了膈下迷走神经切断术对水剥夺大鼠在 1 小时内摄入 0.5mol/L 蔗糖、0.005mol/L 糖精或蒸馏水的影响。结果显示，在迷走神经切断大鼠中，这三种溶液的消耗量没有显著差异。然而，假手术组大鼠饮用的糖精溶液多于蔗糖溶液或蒸馏水。此外，迷走神经切断大鼠的蒸馏水摄入量与假手术组大鼠相似，但迷走神经切断大鼠的蔗糖和糖精摄入量明显低于假手术组大鼠。这些发现表明，膈下迷走神经切断术减少了大鼠对甜味溶液的摄入，提示迷走神经和外周传入在控制甜味溶液摄入方面发挥着平衡作用。它们还表明，膈下迷走神经切断术消除了与蒸馏水相比，甜味溶液引起的快感感知差异。
