Sclafani A, Kramer T H
J Auton Nerv Syst. 1983 Oct;9(1):247-58. doi: 10.1016/0165-1838(83)90145-5.
Adult female vagotomized and control (sham-vagotomized) rats were compared in their consumption of saccharin solutions, intake of solid and liquid sucrose, and selection of purified macronutrient diets. In 30 min/day tests the vagotomized rats drank more saccharin solution (0.05, 0.1, 0.2%) than did control rats, while in a 24 h/day test they drank considerably less saccharin solution (0.2%) than did controls. When offered ad libitum access to granular sucrose and lab chow vagotomized rats did not differ from controls in their sucrose intake, chow intake, or total caloric intake. With a 20% sucrose solution and chow available, however, the vagotomized rats consumed significantly less sucrose and total calories than did the controls. Also, unlike the controls, the vagotomized rats did not consume more of the liquid sucrose than of the granular sucrose, and failed to gain weight on the sucrose diets. When maintained on solid macronutrient diets the vagotomized rats were similar to controls in their selection of the fat, carbohydrate and protein diets. The results demonstrate that vagotomy selectively inhibits the intake of sugar solutions and not high-carbohydrate diets in general. Possible explanations for this effect are discussed.
对成年雌性迷走神经切断大鼠和对照（假迷走神经切断）大鼠在糖精溶液消耗量、固体和液体蔗糖摄入量以及纯化常量营养素饮食选择方面进行了比较。在每天30分钟的测试中，迷走神经切断大鼠比对照大鼠饮用更多的糖精溶液（0.05%、0.1%、0.2%），而在每天24小时的测试中，它们饮用的糖精溶液（0.2%）比对照大鼠少得多。当随意提供颗粒状蔗糖和实验室饲料时，迷走神经切断大鼠在蔗糖摄入量、饲料摄入量或总热量摄入方面与对照大鼠没有差异。然而，当提供20%的蔗糖溶液和饲料时，迷走神经切断大鼠消耗的蔗糖和总热量明显低于对照大鼠。此外，与对照大鼠不同，迷走神经切断大鼠消耗的液体蔗糖并不比颗粒状蔗糖多，并且在蔗糖饮食中体重没有增加。当维持在固体常量营养素饮食时，迷走神经切断大鼠在脂肪、碳水化合物和蛋白质饮食选择方面与对照大鼠相似。结果表明，迷走神经切断术选择性地抑制糖溶液的摄入，而不是一般的高碳水化合物饮食的摄入。讨论了这种效应的可能解释。
