College of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan 430061, Hubei Province, China.
Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China.
Neural Regen Res. 2013 Oct 25;8(30):2811-9. doi: 10.3969/j.issn.1673-5374.2013.30.003.
The Alzheimer's disease model in Wistar rats was established by injection of amyloid β-peptide (Aβ1-42) into the hippocampal CA1 region. Rats were treated with suspended moxibustion on Baihui (GV20) and Shenshu (BL23) acupoints. Prior to and post Aβ1-42 exposure. Results showed no evidence of apoptosis in hippocampal neurons, a significantly reduced apoptosis rate of neurons and improved learning and memory abilities were observed in the Alzheimer's disease model. In particular, moxibustion prior to Aβ1-42 exposure was more effective than moxibustion after Aβ1-42 exposure in protecting the neuronal structure and lowering the apoptosis rate. Our findings indicate that a combination of preventive and therapeutic moxibustion has a beneficial effect for the prevention of Alzheimer's disease development.
将淀粉样β肽（Aβ1-42）注入 Wistar 大鼠海马 CA1 区建立阿尔茨海默病模型。在注入 Aβ1-42 前后，对大鼠进行悬灸百会（GV20）和肾俞（BL23）穴位的治疗。结果显示，海马神经元无细胞凋亡证据，阿尔茨海默病模型中神经元的凋亡率显著降低，学习和记忆能力得到改善。特别是，在注入 Aβ1-42 之前进行艾灸比在注入 Aβ1-42 之后进行艾灸更能保护神经元结构和降低凋亡率。我们的研究结果表明，预防性和治疗性艾灸相结合对预防阿尔茨海默病的发展具有有益的效果。
