Department of Anesthesiology, Affiliated Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, China ; Department of Anesthesiology, Shaoxing People's Hospital, Shaoxing, Zhejiang Province, China.
Department of Anesthesiology, Shaoxing People's Hospital, Shaoxing, Zhejiang Province, China.
Neural Regen Res. 2014 Mar 1;9(5):534-9. doi: 10.4103/1673-5374.130084.
Inflammation may play a role in postoperative cognitive dysfunction. 5' Adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-α are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5' adenosine monophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1-7 days after splenectomy. Moreover, interleukin-1β and tumor necrosis factor-α were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats.
炎症可能在术后认知功能障碍中起作用。5' 一磷酸腺苷激活的蛋白激酶、核因子-κB、白细胞介素-1β 和肿瘤坏死因子-α 参与炎症反应。因此,这些炎症介质可能参与术后认知功能障碍。Western 免疫印迹分析显示,脾切除后 1-7 天,老年大鼠海马 5' 一磷酸腺苷激活的蛋白激酶和核因子-κB 增加。此外,白细胞介素-1β 和肿瘤坏死因子-α 上调并逐渐下降。因此,这些炎症介质可能参与老年大鼠脾切除术后认知功能障碍模型。