Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA.
J Intensive Care Med. 2011 Mar-Apr;26(2):73-87. doi: 10.1177/0885066610384188.
A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention.
多种细胞因子在炎症反应中发挥作用。白细胞介素 6（IL-6）型细胞因子在组织损伤或炎症刺激时释放，在局部和全身发挥作用，引起多种生理反应。手术后、创伤后和危重病患者的白细胞介素 6 浓度升高。IL-6 升高的幅度与组织创伤/损伤严重程度相关。此外，IL-6 升高与不良结局相关。白细胞介素 6 水平也可用于对患者进行治疗干预的分层。
