白细胞介素-6 在外科手术、创伤和重症监护中的作用 Ⅱ：临床意义。
Interleukin-6 in surgery, trauma, and critical care part II: clinical implications.
机构信息
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA.
出版信息
J Intensive Care Med. 2011 Mar-Apr;26(2):73-87. doi: 10.1177/0885066610384188.
Abstract
A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention.
摘要
多种细胞因子在炎症反应中发挥作用。白细胞介素 6（IL-6）型细胞因子在组织损伤或炎症刺激时释放，在局部和全身发挥作用，引起多种生理反应。手术后、创伤后和危重病患者的白细胞介素 6 浓度升高。IL-6 升高的幅度与组织创伤/损伤严重程度相关。此外，IL-6 升高与不良结局相关。白细胞介素 6 水平也可用于对患者进行治疗干预的分层。
相似文献
1
Interleukin-6 in surgery, trauma, and critical care part II: clinical implications.白细胞介素-6 在外科手术、创伤和重症监护中的作用 Ⅱ：临床意义。
J Intensive Care Med. 2011 Mar-Apr;26(2):73-87. doi: 10.1177/0885066610384188.
2
Analytic review: Interleukin-6 in surgery, trauma, and critical care: part I: basic science.分析综述：白细胞介素-6 在外科手术、创伤和重症监护中的作用：第一部分：基础科学。
J Intensive Care Med. 2011 Jan-Feb;26(1):3-12. doi: 10.1177/0885066610395678.
3
Is circulating endotoxin the trigger for the systemic inflammatory response syndrome seen after injury?循环内毒素是否为损伤后出现的全身炎症反应综合征的触发因素？
Ann Surg. 1997 May;225(5):530-41; discussion 541-3. doi: 10.1097/00000658-199705000-00010.
4
Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?损伤患者体内的白细胞介素-6：损伤标志物还是炎症介质？
Ann Surg. 1996 Nov;224(5):647-64. doi: 10.1097/00000658-199611000-00009.
5
Activation of markers of inflammation, coagulation and fibrinolysis in musculoskeletal trauma.肌肉骨骼创伤中炎症、凝血和纤维蛋白溶解标志物的激活
PLoS One. 2014 Nov 3;9(11):e107881. doi: 10.1371/journal.pone.0107881. eCollection 2014.
6
Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model.白三烯 B4 表明猪的长期模型中严重创伤后肺损伤和持续的炎症变化。
Prostaglandins Leukot Essent Fatty Acids. 2017 Dec;127:25-31. doi: 10.1016/j.plefa.2017.09.014. Epub 2017 Sep 22.
7
The early second hit in trauma management augments the proinflammatory immune response to multiple injuries.创伤管理中的早期二次打击会增强对多发伤的促炎免疫反应。
J Trauma. 2007 Jun;62(6):1396-403; discussion 1403-4. doi: 10.1097/TA.0b013e318047b7f0.
8
The acute inflammatory response after trauma is heightened by frailty: A prospective evaluation of inflammatory and endocrine system alterations in frailty.创伤后急性炎症反应会因虚弱而加剧：对虚弱患者炎症和内分泌系统改变的前瞻性评估。
J Trauma Acute Care Surg. 2019 Jul;87(1):54-60. doi: 10.1097/TA.0000000000002229.
9
Induction of interleukin-1 receptor antagonist (IL-1ra) following surgery is associated with major trauma.手术后白细胞介素-1受体拮抗剂（IL-1ra）的诱导与严重创伤有关。
Clin Immunol Immunopathol. 1995 Jul;76(1 Pt 1):96-101. doi: 10.1006/clin.1995.1093.
10
Trauma-induced secondary cardiac injury is associated with hyperacute elevations in inflammatory cytokines.创伤性继发性心脏损伤与炎症细胞因子的超急性升高有关。
Shock. 2013 May;39(5):415-20. doi: 10.1097/SHK.0b013e31828ded41.
引用本文的文献
1
In Vivo Antibiotic Elution and Inflammatory Response During Two-Stage Total Knee Arthroplasty Revision: A Microdialysis Pilot Study.两阶段全膝关节置换翻修术中的体内抗生素洗脱及炎症反应：一项微透析初步研究
Antibiotics (Basel). 2025 Jul 24;14(8):742. doi: 10.3390/antibiotics14080742.
2
Clinical and biological impact of conversion on outcomes of minimally invasive liver surgery: a multimodal analysis.转化对微创肝脏手术结局的临床和生物学影响：多模态分析
Updates Surg. 2025 Aug 19. doi: 10.1007/s13304-025-02375-y.
3
Multiaxial rotational loading compromises the transition zone of the intervertebral disc: Ex vivo study using next-generation bioreactors.多轴旋转加载会损害椎间盘的过渡区：使用新一代生物反应器的体外研究。
Bioeng Transl Med. 2025 Jun 8;10(4):e70033. doi: 10.1002/btm2.70033. eCollection 2025 Jul.
4
The effects of honey solution on postoperative stress, gastric motility, and patient comfort: a randomized controlled trial.蜂蜜溶液对术后应激、胃动力及患者舒适度的影响：一项随机对照试验。
Croat Med J. 2025 Jul 5;66(3):204-212.
5
Biomarkers for pneumonia after major trauma: A systematic review and meta-analysis.重大创伤后肺炎的生物标志物：系统评价与荟萃分析
J Intensive Care Soc. 2025 Jun 13:17511437251344068. doi: 10.1177/17511437251344068.
6
Effect of Herbal Bioactive Compounds on the Angiogenic Factors and Modulation of Inflammatory Mediators in the Patients with the Deep Second-Degree Burn: A Single-Blinded, Randomized Clinical Trial.草药生物活性化合物对深二度烧伤患者血管生成因子及炎症介质调节的影响：一项单盲随机临床试验
Med J Islam Repub Iran. 2025 Jan 28;39:16. doi: 10.47176/mjiri.39.16. eCollection 2025.
7
Impact of Large-Volume Liposuction on Inflammatory Cytokine Interleukin-6 Levels: A Cross-Sectional Study.大容量抽脂术对炎性细胞因子白细胞介素-6水平的影响：一项横断面研究。
Aesthet Surg J Open Forum. 2025 Apr 12;7:ojaf021. doi: 10.1093/asjof/ojaf021. eCollection 2025.
8
Cephalomedullary Nailing vs. Dynamic Hip Screw for the Treatment of Pertrochanteric Fractures: The Role of Cytokines in the Prediction of Surgical Invasiveness.髓内钉与动力髋螺钉治疗股骨转子间骨折：细胞因子在预测手术侵袭性中的作用
J Clin Med. 2025 Mar 8;14(6):1825. doi: 10.3390/jcm14061825.
9
Evaluation of the Timing to Noncardiac Surgery following Cardiac Operations: A National Analysis.心脏手术后非心脏手术时机的评估：一项全国性分析。
JACC Adv. 2025 Apr;4(4):101668. doi: 10.1016/j.jacadv.2025.101668. Epub 2025 Mar 19.
10
Acute inflammatory profile of patients submitted to pulmonary resection.接受肺切除术患者的急性炎症特征
Acta Cir Bras. 2025 Feb 3;40:e401625. doi: 10.1590/acb401625. eCollection 2025.
本文引用的文献
1
The early IL-6 and IL-10 response in trauma is correlated with injury severity and mortality.创伤早期白细胞介素-6和白细胞介素-10反应与损伤严重程度及死亡率相关。
Acta Anaesthesiol Scand. 2009 Apr;53(4):515-21. doi: 10.1111/j.1399-6576.2008.01801.x.
2
Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study.Toll样受体4基因变异影响创伤后器官衰竭和休克风险：一项队列研究
J Trauma. 2009 Jan;66(1):115-22; discussion 122-3. doi: 10.1097/TA.0b013e3181938d50.
3
Th1- and Th2-type cytokines in plasma after major trauma.严重创伤后血浆中的Th1型和Th2型细胞因子。
J Trauma. 2008 Dec;65(6):1374-8. doi: 10.1097/TA.0b013e31818b257d.
4
Neuroinflammation facilitates LIF entry into brain: role of TNF.神经炎症促进白血病抑制因子进入大脑：肿瘤坏死因子的作用。
Am J Physiol Cell Physiol. 2008 Jun;294(6):C1436-42. doi: 10.1152/ajpcell.00489.2007. Epub 2008 Apr 2.
5
6
Surgical trauma-induced adrenal insufficiency is associated with postoperative inflammatory responses.手术创伤所致肾上腺功能不全与术后炎症反应相关。
J Nippon Med Sch. 2007 Aug;74(4):274-83. doi: 10.1272/jnms.74.274.
7
IL-6 modulates sepsis-induced decreases in transcription of hepatic organic anion and bile acid transporters.白细胞介素-6调节脓毒症诱导的肝脏有机阴离子和胆汁酸转运体转录水平降低。
Shock. 2008 Apr;29(4):490-6. doi: 10.1097/shk.0b013e318150762b.
8
A new qualitative interleukin-6 bedside test can predict pneumonia in patients with severe head injury--comparison to the standard Immulite test and a semiquantitative bedside test.
J Neurosurg Anesthesiol. 2007 Jan;19(1):5-9. doi: 10.1097/01.ana.0000211026.18926.89.
9
Intestinal permeability and cytokine inflammatory response in multiply injured patients.多发伤患者的肠道通透性和细胞因子炎症反应
J Interferon Cytokine Res. 2006 Oct;26(10):771-6. doi: 10.1089/jir.2006.26.771.
10
HLA-DR expression on monocytes and systemic inflammation in patients with ruptured abdominal aortic aneurysms.腹主动脉瘤破裂患者单核细胞上的HLA - DR表达与全身炎症
Crit Care. 2006;10(4):R119. doi: 10.1186/cc5017.
Zotero 插件