患有红斑狼疮的女性每日褪黑素水平降低——一份简短报告。
Decreased daily melatonin levels in women with systemic lupus erythematosus - a short report.
机构信息
Clinical Center of Endocrinology and Gerontology, Medical University Sofia, Medical Faculty, Sofia, Bulgaria.
Clinic of Rheumatology, Medical University Sofia, Medical Faculty, Sofia, Bulgaria.
出版信息
Balkan Med J. 2013 Sep;30(3):273-6. doi: 10.5152/balkanmedj.2013.8064. Epub 2013 Sep 1.
BACKGROUND
The neuroendocrine system is known to influence immunity, but the precise interactions between different hormones and autoimmune disorders remain obscure.
AIMS
The present study aimed to investigate the role of daily serum melatonin concentrations in the development of systemic lupus erythematosus (SLE) in women.
STUDY DESIGN
Case-control study.
METHODS
One-hundred and eleven SLE female patients and 46 healthy women were included in the study. Daily serum melatonin levels were investigated in all participants.
RESULTS
SLE patients showed significantly lower daily melatonin levels in comparison to healthy women during the short photoperiod (17.75±7.13 pg/mL [16.05] vs. 21.63±6.60 pg/mL [20.10], p=0.012). Hormone concentrations were inversely related to the SLE activity index (SLEDAI) (r= -0.268, p=0.004), but they did not correlate to any particular American College Rheumatology (ACR) criterion (p>0.05 for all).
CONCLUSION
Daily melatonin levels were decreased in women with systemic lupus erythematosus and correlated inversely to the activity of the autoimmune disease. Further studies are needed to clarify the importance of the pineal and extrapineal melatonin secretion in patients with systemic lupus erythematosus as well as the interrelations between hormones and autoimmunity.
背景
已知神经内分泌系统会影响免疫，但不同激素与自身免疫性疾病之间的确切相互作用仍不清楚。
目的
本研究旨在探讨女性血清褪黑素浓度日变化在系统性红斑狼疮（SLE）发病中的作用。
研究设计
病例对照研究。
方法
本研究纳入了 111 例 SLE 女性患者和 46 名健康女性。所有参与者均检测了每日血清褪黑素水平。
结果
与健康女性相比，SLE 患者在短光照期的每日褪黑素水平明显较低（17.75±7.13 pg/mL [16.05] 与 21.63±6.60 pg/mL [20.10]，p=0.012）。激素浓度与 SLE 活动指数（SLEDAI）呈负相关（r= -0.268，p=0.004），但与任何特定的美国风湿病学会（ACR）标准均无相关性（p＞0.05）。
结论
系统性红斑狼疮女性的每日褪黑素水平降低，与自身免疫性疾病的活动度呈负相关。需要进一步研究以阐明松果腺和松果腺外褪黑素分泌在系统性红斑狼疮患者中的重要性，以及激素与自身免疫之间的相互关系。
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