Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Osteoporos Int. 2023 Oct;34(10):1677-1701. doi: 10.1007/s00198-023-06836-1. Epub 2023 Jul 2.
Bone diseases account for an enormous cost burden on health systems. Bone disorders are considered as age-dependent diseases. The aging of world population has encouraged scientists to further explore the most effective preventive modalities and therapeutic strategies to overcome and reduce the high cost of bone disorders. Herein, we review the current evidence of melatonin's therapeutic effects on bone-related diseases.
This review summarized evidences from in vitro, in vivo, and clinical studies regarding the effects of melatonin on bone-related diseases, with a focus on the molecular mechanisms. Electronically, Scopus and MEDLINE®/PubMed databases were searched for articles published on melatonin and bone-related diseases from inception to June 2023.
The findings demonstrated that melatonin has beneficial effect in bone- and cartilage-related disorders such as osteoporosis, bone fracture healing, osteoarthritis, and rheumatoid arthritis, in addition to the control of sleep and circadian rhythms.
A number of animal and clinical studies have indicated that various biological effects of melatonin may suggest this molecule as an effective therapeutic agent for controlling, diminishing, or suppressing bone-related disorders. Therefore, further clinical studies are required to clarify whether melatonin can be effective in patients with bone-related diseases.
骨骼疾病给医疗系统带来了巨大的经济负担。骨骼疾病被认为是与年龄相关的疾病。世界人口老龄化促使科学家进一步探索最有效的预防方式和治疗策略，以克服和降低骨骼疾病的高成本。在此，我们综述了褪黑素在骨骼相关疾病治疗方面的现有证据。
本综述总结了关于褪黑素对骨骼相关疾病的影响的体外、体内和临床研究证据，重点关注分子机制。我们通过电子检索 Scopus 和 MEDLINE®/PubMed 数据库，检索了截至 2023 年 6 月关于褪黑素与骨骼相关疾病的文章。
研究结果表明，褪黑素对骨质疏松症、骨折愈合、骨关节炎和类风湿性关节炎等骨骼和软骨相关疾病具有有益作用，除此之外，它还能控制睡眠和昼夜节律。
一些动物和临床研究表明，褪黑素的多种生物学效应可能表明该分子是控制、减轻或抑制骨骼相关疾病的有效治疗剂。因此，需要进一步的临床研究来阐明褪黑素是否对骨骼相关疾病患者有效。
