Department of Obstetrics and Gynecology, Trakya University Faculty of Medicine, Edirne, Turkey.
Eurofertil Reproductive Health Center, İstanbul, Turkey.
Balkan Med J. 2013 Dec;30(4):406-9. doi: 10.5152/balkanmedj.2013.9028. Epub 2013 Dec 1.
GnRH agonists and antagonists have different mechanism of action, and therefore serum estradiol levels might differ during coasting in IVF.
To compare the change in serum oestradiol levels after withholding the gonadotropins for coasting between long agonist and antagonist cycles.
Retrospective study.
Antagonist and long agonist cycles, in which coasting was performed, were analysed in this retrospective analysis. Antagonist cycles (n=50) were compared with long agonist cycles (n=52) with respect to daily serum oestradiol levels following withholding of gonadotropins.
The pattern of change in serum oestradiol was different between groups; it increased on the first day by 11.2% and decreased thereafter on the second and third days in the agonist group. However, it began to decrease from the first day in the antagonist group. Therefore, peak serum oestradiol levels were significantly higher in the agonist group than in the antagonist group (mean±standard deviation; 5798±1748 vs 5104±1351 pg/mL). The duration of coasting was shorter in the antagonist group compared with that in the agonist group (mean±standard deviation; 2.60±1.40 vs 1.96±0.88 days).
Serum oestradiol pattern during coasting is different in antagonist cycles compared with long agonist cycles in in vitro fertilisation.
促性腺激素释放激素激动剂和拮抗剂具有不同的作用机制，因此在体外受精的 coasting 过程中血清雌二醇水平可能不同。
比较长激动剂和拮抗剂周期 coasting 期间停用促性腺激素后血清雌二醇水平的变化。
回顾性研究。
在这项回顾性分析中，分析了使用 coasting 的拮抗剂周期（n=50）和长激动剂周期（n=52）。拮抗剂周期与长激动剂周期相比，比较了停用促性腺激素后每日血清雌二醇水平的变化。
两组血清雌二醇水平的变化模式不同；在激动剂组，它在第一天增加了 11.2%，然后在第二天和第三天下降。然而，在拮抗剂组，它从第一天开始下降。因此，激动剂组的峰值血清雌二醇水平明显高于拮抗剂组（平均值±标准差；5798±1748 vs 5104±1351 pg/mL）。拮抗剂组的 coasting 持续时间比激动剂组短（平均值±标准差；2.60±1.40 vs 1.96±0.88 天）。
在体外受精中，拮抗剂周期与长激动剂周期相比，coasting 期间血清雌二醇的模式不同。
