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人皮肤利什曼病病变的蛋白质组谱分析。

Proteome profiling of human cutaneous leishmaniasis lesion.

机构信息

Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Brazil.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

出版信息

J Invest Dermatol. 2015 Feb;135(2):400-410. doi: 10.1038/jid.2014.396. Epub 2014 Sep 10.

DOI:10.1038/jid.2014.396
PMID:25207817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4291685/
Abstract

In this study, we used proteomics and biological network analysis to evaluate the potential biological processes and components present in the identified proteins of biopsies from cutaneous leishmaniasis (CL) patients infected by Leishmania braziliensis in comparison with normal skin. We identified 59 proteins differently expressed in samples from infected and normal skin. Biological network analysis employing identified proteins showed the presence of networks that may be involved in the cell death mediated by cytotoxic T lymphocytes. After immunohistochemical analyses, the expression of caspase-9, caspase-3, and granzyme B was validated in the tissue and positively correlated with the lesion size in CL patients. In conclusion, this work identified differentially expressed proteins in the inflammatory site of CL, revealed enhanced expression of caspase-9, and highlighted mechanisms associated with the progression of tissue damage observed in lesions.

摘要

在这项研究中，我们使用蛋白质组学和生物网络分析来评估巴西利什曼原虫感染的皮肤利什曼病（CL）患者活检中鉴定的蛋白质所存在的潜在生物学过程和成分与正常皮肤进行比较。我们在感染和正常皮肤样本中鉴定了 59 种差异表达的蛋白质。使用鉴定出的蛋白质进行的生物网络分析表明，可能存在涉及细胞毒性 T 淋巴细胞介导的细胞死亡的网络。经过免疫组织化学分析，在组织中验证了半胱天冬酶-9、半胱天冬酶-3 和颗粒酶 B 的表达，并与 CL 患者病变的大小呈正相关。总之，这项工作鉴定了 CL 炎症部位差异表达的蛋白质，揭示了半胱天冬酶-9 的表达增强，并强调了与病变中观察到的组织损伤进展相关的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/081c49485f00/jid2014396f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/5585d214623b/jid2014396f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/a445a8ca3fe3/jid2014396f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/32f9dc3ce35c/jid2014396f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/8ec9e4735895/jid2014396f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/469a3e3c76fa/jid2014396f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/081c49485f00/jid2014396f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/5585d214623b/jid2014396f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/a445a8ca3fe3/jid2014396f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/32f9dc3ce35c/jid2014396f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/8ec9e4735895/jid2014396f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/469a3e3c76fa/jid2014396f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f2/4291685/081c49485f00/jid2014396f6.jpg

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[4]
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[5]
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[6]
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[8]
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本文引用的文献

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J Invest Dermatol. 2013-1-15

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Parasite Immunol. 2012-12

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