三萜酸类化合物抗肿瘤作用研究综述
Review on anti-tumor effect of triterpene acid compounds.
作者信息
Zhang Weisan, Men Xiaoyan, Lei Ping
机构信息
Department of Geriatrics, Tianjin Geriatric Institute, Tianjin Medical University General Hospital, Tianjin, China.
出版信息
J Cancer Res Ther. 2014 Aug;10 Suppl 1:14-9. doi: 10.4103/0973-1482.139746.
PMID:25207885
Abstract
Recent studies have found that triterpene acid type compounds has many effects including antiinflammatory, regulating blood sugar level, antiviral and antitumor activity. More importantly, triterpene acid type compounds has become one of the most popular topics recently because its selective toxic effects on cancer cells and harmless to normal cells at the same time. This review summarized the antitumor activity and the mechanism of triterpene acid type compounds, providing guideline for further research and development of new antitumor natural products.
摘要
近年来的研究发现，三萜酸类化合物具有多种作用，包括抗炎、调节血糖水平、抗病毒和抗肿瘤活性。更重要的是，三萜酸类化合物因其对癌细胞具有选择性毒性作用而对正常细胞无害，已成为近年来最热门的话题之一。本文综述了三萜酸类化合物的抗肿瘤活性及其作用机制，为进一步研发新型抗肿瘤天然产物提供参考。
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