Wei Niu, Bin Shi, Jing Zhou, Wei Sun, Yingqiong Zhao
Am J Dent. 2014 Jun;27(3):171-6.
To evaluate the short- and mid-term effects of commercial pure (cp) titanium implant surface topography on osseointegration, bone-regenerative potential and mechanical retention in the human maxilla and mandible.
32 micro-implants with the same geometry but with four different surface treatments were implanted in the maxilla and mandible of eight patients. Each patient received four micro-implants, one of each type. Percentage of bone-to-implant contact analysis and histological evaluation was carried 3, 6 and 12 weeks after implantation. Furthermore, reverse removal torque tests were conducted 3 and 6 weeks after implantation to analyze functional bone attachment. Implant surfaces tested were: machined, grit-blasted, acid-etched, and grit-blasted with acid-etch. One-way ANOVA was performed using the multiple comparison Fisher's test to determine significance of observed differences among test groups. The level of significance was established at 5% (P < 0.05). Mean and standard deviations of the test groups were calculated.
Surface roughness had a significant correlation with the evolution of bone regeneration. The surfaces with roughness Ra approximately 4 microim (grit-blasted and grit-blasted with acid-etch), showed rapid tissue colonization compared to machine and acid-etched surfaces. The results of reverse removal torque tests confirmed a significant correlation between surface roughness and functional bone attachment. Grit-blasted and grit-blasted with acid etched surfaces showed higher retention values compared to machine and acid-etched implants. This finding was supported by higher bone-to-implant contact observed for rougher surfaces (grit-blasted and grit-blasted with acid etching).
评估商用纯钛（cp）种植体表面形貌对人上颌骨和下颌骨骨整合、骨再生潜力及机械固位的短期和中期影响。
将32枚几何形状相同但经过四种不同表面处理的微型种植体植入8例患者的上颌骨和下颌骨。每位患者接受四枚微型种植体，每种类型各一枚。在植入后3、6和12周进行骨与种植体接触分析的百分比及组织学评估。此外，在植入后3和6周进行反向拆除扭矩测试，以分析功能性骨附着情况。测试的种植体表面包括：机械加工表面、喷砂表面、酸蚀表面以及喷砂加酸蚀表面。使用多重比较费舍尔检验进行单因素方差分析，以确定各测试组间观察到的差异的显著性。显著性水平设定为5%（P < 0.05）。计算测试组的均值和标准差。
表面粗糙度与骨再生的进展显著相关。粗糙度Ra约为4微米的表面（喷砂表面和喷砂加酸蚀表面）与机械加工表面和酸蚀表面相比，显示出更快的组织定植。反向拆除扭矩测试结果证实表面粗糙度与功能性骨附着之间存在显著相关性。与机械加工和酸蚀种植体相比，喷砂表面和喷砂加酸蚀表面显示出更高的固位值。这一发现得到了较粗糙表面（喷砂表面和喷砂加酸蚀表面）更高的骨与种植体接触率的支持。
