Lewandowski Adam J, Leeson Paul
Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Early Hum Dev. 2014 Nov;90(11):725-9. doi: 10.1016/j.earlhumdev.2014.08.012. Epub 2014 Sep 7.
Investigations into how perinatal growth and intrauterine environment may 'programme' risk of later cardiovascular disease have been ongoing for over two decades. One of the more recent outcomes of these studies is the observation that certain pregnancy-related conditions, such as preterm birth, have an unusually large impact on the long-term cardiovascular health of the offspring. In the present paper, we review the current literature of how preterm birth affects the long-term cardiovascular structure and function of the offspring, considering three major areas of investigation: firstly, outlining the long-term cardiovascular phenotypic changes in preterm-born individuals; secondly, investigating factors related to preterm birth that may be modifying cardiovascular phenotype, such as preeclampsia, perinatal interventions, and physiological disturbances; and thirdly, the expected clinical relevance of these cardiovascular changes. This review discusses the importance of continued research focused on the mechanistic understanding of these cardiovascular alterations in order to develop specific primary prevention strategies.
关于围产期生长和子宫内环境如何“编程”后期心血管疾病风险的研究已经持续了二十多年。这些研究的最新成果之一是观察到某些与妊娠相关的情况，如早产，对后代的长期心血管健康有异常大的影响。在本文中，我们回顾了关于早产如何影响后代长期心血管结构和功能的当前文献，考虑了三个主要研究领域：第一，概述早产个体的长期心血管表型变化；第二，研究与早产相关的可能改变心血管表型的因素，如先兆子痫、围产期干预和生理紊乱；第三，这些心血管变化的预期临床相关性。本综述讨论了持续研究的重要性，该研究聚焦于对这些心血管改变的机制理解，以便制定具体的一级预防策略。
