Nuyt Anne Monique, Lavoie Jean-Claude, Mohamed Ibrahim, Paquette Katryn, Luu Thuy Mai
Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Research Center, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, 3175 chemin de la Côte-Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada.
Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Research Center, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, 3175 chemin de la Côte-Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada; Department of Nutrition, Faculty of Medicine, Research Center, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, 3175 chemin de la Côte-Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada.
Clin Perinatol. 2017 Jun;44(2):315-332. doi: 10.1016/j.clp.2017.01.010. Epub 2017 Mar 18.
Extremely preterm babies are exposed to various sources of injury during critical stages of development. The extremely preterm infant faces premature transition to ex utero physiology and undergoes adaptive mechanisms that may be deleterious in the long term because of permanent alterations in organ structure and function. Perinatal events can also directly cause structural injury. These disturbances induce morphologic and functional changes in their organ systems that might heighten their risks for later adult chronic diseases. This review examines the pathophysiology of programming of long-term health and diseases after preterm birth and associated perinatal risk factors.
极早产儿在发育的关键阶段会受到各种损伤源的影响。极早产儿面临过早向宫外生理状态过渡，并经历一些适应性机制，从长远来看，这些机制可能是有害的，因为器官结构和功能会发生永久性改变。围产期事件也可直接导致结构性损伤。这些干扰会引起其器官系统的形态和功能变化，可能会增加他们日后患成人慢性疾病的风险。本综述探讨早产及相关围产期危险因素后长期健康和疾病编程的病理生理学。
