Keles Sadullah, Ates Orhan, Kartal Baki, Alp Hamit Hakan, Ekinci Metin, Ceylan Erdinc, Ondas Osman, Arpali Eren, Dogan Semih, Yildirim Kenan, Keles Mevlut Sait
Department of Ophthalmology, School of Medicine, Ataturk University, Erzurum, Turkey.
Department of Ophthalmology, Regional Training and Research Hospital, Erzurum, Turkey.
Clin Ophthalmol. 2014 Aug 25;8:1573-8. doi: 10.2147/OPTH.S66160. eCollection 2014.
To evaluate levels of homocysteine, asymmetric dimethylarginine (ADMA), and nitric oxide (NO), as well as activity of endothelial NO synthase (eNOS), in patients with age-related macular degeneration (AMD).
The levels of homocysteine, ADMA, and NO and activity of eNOS in patients who were diagnosed with wet AMD by fundus fluorescein angiography (n=30) were compared to a control group with no retinal pathology (n=30).
Levels of homocysteine and ADMA were found to be significantly higher in the wet AMD group than in the control group (P<0.001), whereas NO levels and eNOS activity were higher in the control group (P<0.001). In the wet AMD group, we detected a 2.64- and 0.33-fold increase in the levels of ADMA and homocysteine, respectively, and a 0.49- and 2.41-fold decrease in the eNOS activity and NO level, respectively.
Elevated levels of homocysteine and ADMA were observed in patients with wet AMD. Increased ADMA may be responsible for the diminished eNOS activity found in these patients, which in turn contributes to the decrease in NO levels, which likely plays a role in the pathogenesis of AMD.
评估年龄相关性黄斑变性（AMD）患者体内同型半胱氨酸、不对称二甲基精氨酸（ADMA）和一氧化氮（NO）的水平，以及内皮型一氧化氮合酶（eNOS）的活性。
通过眼底荧光血管造影诊断为湿性AMD的患者（n = 30），将其体内同型半胱氨酸、ADMA和NO的水平以及eNOS的活性与无视网膜病变的对照组（n = 30）进行比较。
发现湿性AMD组的同型半胱氨酸和ADMA水平显著高于对照组（P < 0.001），而对照组的NO水平和eNOS活性更高（P < 0.001）。在湿性AMD组中，我们检测到ADMA和同型半胱氨酸水平分别升高了2.64倍和0.33倍，eNOS活性和NO水平分别降低了0.49倍和2.41倍。
在湿性AMD患者中观察到同型半胱氨酸和ADMA水平升高。ADMA增加可能是这些患者中eNOS活性降低的原因，这反过来又导致NO水平降低，而NO水平降低可能在AMD的发病机制中起作用。
