Demir B, Demir S, Pasa S, Guven S, Atamer Y, Atamer A, Kocyigit Y
Ergani State Hospital, Department of Obstetrics and Gynecology, Diyarbakir, Turkey.
J Obstet Gynaecol. 2012 Aug;32(6):525-8. doi: 10.3109/01443615.2012.693985.
Nitric oxide (NO) contributes to vasodilatation that is observed during normal pregnancy. Hyperhomocysteinaemia (HHcy) is a vascular risk factor associated with placental microvascular diseases and pre-eclampsia. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (NOS) has been linked to endothelial dysfunction. Maternal ADMA has been reported to be higher in women with pre-eclampsia and HHcy leads to accumulation of ADMA. The aim of this presented study is to evaluate the alterations of plasma homocysteine, ADMA and NO levels in mild pre-eclampsia. A total of 40 pre-eclamptic women and 40 healthy controls were included into the study. Mean systolic and diastolic blood pressure, mean serum homocysteine and ADMA levels were significantly higher and NO level was lower in patients. Serum homocysteine, ADMA and NO levels found to be correlated among them and with blood pressure. In conclusion, we found that homocysteine and ADMA levels were increased and NO levels decreased in pre-eclampsia.
一氧化氮（NO）有助于正常妊娠期间出现的血管舒张。高同型半胱氨酸血症（HHcy）是一种与胎盘微血管疾病和先兆子痫相关的血管危险因素。非对称二甲基精氨酸（ADMA）是内皮型一氧化氮合酶（NOS）的内源性抑制剂，与内皮功能障碍有关。据报道，先兆子痫女性的母体ADMA水平较高，且HHcy会导致ADMA积累。本研究的目的是评估轻度先兆子痫患者血浆同型半胱氨酸、ADMA和NO水平的变化。共有40例先兆子痫女性和40例健康对照纳入研究。患者的平均收缩压和舒张压、平均血清同型半胱氨酸和ADMA水平显著升高，而NO水平降低。血清同型半胱氨酸、ADMA和NO水平之间以及与血压之间均存在相关性。总之，我们发现先兆子痫患者的同型半胱氨酸和ADMA水平升高，而NO水平降低。
