Trzepacz P T, Sclabassi R J, Van Thiel D H
University of Pittsburgh School of Medicine, Pennsylvania.
J Neuropsychiatry Clin Neurosci. 1989 Summer;1(3):283-90. doi: 10.1176/jnp.1.3.283.
Evoked potentials of 23 patients with chronic liver disease and delirium were compared with those of matched controls without delirium. Delirious subjects had significantly worse scores on the Mini-Mental State Exam and Trail Making Tests. Mean peak activity from computerized spectral analysis of the EEG was lower in delirious subjects than in nondelirious subjects (7.5 +/- 3.8 cycles per second (cps) and 9.5 +/- 3.2 cps, respectively). Mean auditory brainstem evoked potentials were abnormal in both groups, with delirious subjects showing a bimodal distribution of latency values and a greater proportion of abnormal values. Somatosensory evoked potentials were abnormal for delirious patients and normal for controls, and the differences were significant. The data suggest that the underlying pathophysiology of delirium may lie, at least in part, at the subcortical level.
将23例患有慢性肝病且伴有谵妄的患者的诱发电位与相匹配的无谵妄对照组患者的诱发电位进行了比较。谵妄患者在简易精神状态检查和连线测验中的得分明显更低。通过脑电图的计算机频谱分析得出，谵妄患者的平均峰值活动低于非谵妄患者（分别为每秒7.5±3.8个周期和每秒9.5±3.2个周期）。两组的平均听觉脑干诱发电位均异常，谵妄患者的潜伏期值呈双峰分布，且异常值的比例更高。谵妄患者的体感诱发电位异常，而对照组正常，差异具有显著性。数据表明，谵妄的潜在病理生理学可能至少部分存在于皮层下水平。
