Novais Jussara de Souza Mayrink, Benetti-Pinto Cristina Laguna, Garmes Heraldo Mendes, Jales Rodrigo Menezes, Juliato Cássia Raquel Teatin
Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas (UNICAMP) , Campinas, São Paulo , Brazil and.
Gynecol Endocrinol. 2015 Jan;31(1):48-51. doi: 10.3109/09513590.2014.958990. Epub 2014 Sep 11.
Polycystic ovary syndrome (PCOS) has been associated with an autoimmune origin, either per se or favoring the onset of autoimmune diseases, from a stimulatory action on the inflammatory response. Thus, autoimmune thyroiditis (AIT) could be more prevalent among women with PCOS.
To evaluate the prevalence of AIT in women with PCOS.
It was a cross-sectional study, in a tertiary center, including 65 women with PCOS and 65 women without this condition. Clinical and laboratory parameters were evaluated and a thyroid ultrasound scan was performed. Levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), anti-thyroid peroxidase (anti-TPO) antibodies, anti-thyroglobulin (anti-TG) antibodies, and thyroid ultrasound findings were evaluated.
The prevalence of subclinical hypothyroidism (SCH) in women with PCOS was 16.9% and 6.2% in the non-PCOS group. AIT was more common in the PCOS group compared with the non-PCOS group (43.1% versus 26.2%). But, when it was adjusted by weight and insulin resistance, the difference in the thyroiditis risk was not observed (OR 0.78, CI 0.28-2.16).
AIT risk was similar in the PCOS and the non-PCOS group. SCH are more common in women with PCOS, highlighting a need for periodic monitoring of thyroid function.
多囊卵巢综合征（PCOS）与自身免疫起源有关，无论是其本身还是通过对炎症反应的刺激作用，促进自身免疫性疾病的发生。因此，自身免疫性甲状腺炎（AIT）在PCOS女性中可能更为普遍。
评估PCOS女性中AIT的患病率。
这是一项在三级中心进行的横断面研究，纳入65例PCOS女性和65例非PCOS女性。评估临床和实验室参数，并进行甲状腺超声检查。评估促甲状腺激素（TSH）、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）、抗甲状腺过氧化物酶（抗-TPO）抗体、抗甲状腺球蛋白（抗-TG）抗体水平以及甲状腺超声检查结果。
PCOS女性中亚临床甲状腺功能减退（SCH）的患病率为16.9%，非PCOS组为6.2%。与非PCOS组相比，AIT在PCOS组中更为常见（43.1%对26.2%）。但是，在根据体重和胰岛素抵抗进行调整后，未观察到甲状腺炎风险的差异（OR 0.78，CI 0.28 - 2.16）。
PCOS组和非PCOS组的AIT风险相似。SCH在PCOS女性中更为常见，这突出了定期监测甲状腺功能的必要性。
