Abdul-Ameer Fatima, AlAsadi Itlal Jummha AbudlRasool, Hosseini Asieh, Bahreini Elham
Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, P.O. Box: 1449614525, Tehran, Iran.
College of Medicine, University of Karbala, Karbala, Iraq.
BMC Endocr Disord. 2024 Dec 18;24(1):272. doi: 10.1186/s12902-024-01801-3.
Many patients with polycystic ovary syndrome (PCOS) also experience thyroid disorders. There is a notable similarity in energy metabolism among PCOS, C1q/tumor necrosis factor (TNF)-related proteins (CTRP-5)deficiency, C3a/desArg (also known as acylation-stimulating protein (ASP)) deficiency, and hypothyroidism. This study aimed to investigate the relationship between serum levels of these factors and hypothyroidism in patients with PCOS. Improved clarity and vocabulary, corrected minor grammatical issues, and enhanced readability.
This case-control study involved three groups: healthy women (control group), women with PCOS and hypothyroidism, and women with PCOS without hypothyroidism. Serum levels of FBS, total cholesterol, triglycerides, and HDL-C were measured using enzymatic and colorimetric methods. TSH, T4, T3, and anti-thyroid peroxidase (Anti-TPO) levels were determined by ELISA to screen for hypothyroidism in women with PCOS. Additionally, serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), CTRP-5, ASP, and complement C3 were assessed using the ELISA method.
The results indicated that reduced blood levels of CTRP-5, along with elevated levels of ASP (C3a/desArg) and complement C3 in patients with PCOS, may be linked to dysregulation of the thyroid gland. Furthermore, the study observed that changes in these parameters, in conjunction with thyroid dysfunction, are associated with pathological alterations in lipid profiles and blood glucose levels.
While changes in CTRP-5, ASP, and complement C3 can influence energy expenditure and storage in PCOS and thyroid function, the complex nature of PCOS requires further research to investigate the prevalence of hypothyroidism in individuals with PCOS.
Not applicable.
许多多囊卵巢综合征（PCOS）患者也患有甲状腺疾病。PCOS、C1q/肿瘤坏死因子（TNF）相关蛋白（CTRP-5）缺乏、C3a/去精氨酸（也称为酰化刺激蛋白（ASP））缺乏和甲状腺功能减退患者在能量代谢方面存在显著相似性。本研究旨在探讨这些因素的血清水平与PCOS患者甲状腺功能减退之间的关系。提高了清晰度和词汇量，纠正了一些小语法问题，并增强了可读性。
本病例对照研究分为三组：健康女性（对照组）、患有PCOS和甲状腺功能减退的女性以及患有PCOS但无甲状腺功能减退的女性。采用酶法和比色法测量空腹血糖（FBS）、总胆固醇、甘油三酯和高密度脂蛋白胆固醇（HDL-C）的血清水平。通过酶联免疫吸附测定（ELISA）法测定促甲状腺激素（TSH）、甲状腺素（T4）、三碘甲状腺原氨酸（T3）和抗甲状腺过氧化物酶（Anti-TPO）水平，以筛查PCOS女性的甲状腺功能减退。此外，采用ELISA法评估黄体生成素（LH）、卵泡刺激素（FSH）、CTRP-5、ASP和补体C3的血清水平。
结果表明，PCOS患者血清CTRP-5水平降低，同时ASP（C3a/去精氨酸）和补体C3水平升高，可能与甲状腺功能失调有关。此外，研究观察到这些参数的变化与甲状腺功能障碍一起，与血脂谱和血糖水平的病理改变有关。
虽然CTRP-5、ASP和补体C3的变化会影响PCOS患者的能量消耗和储存以及甲状腺功能，但PCOS的复杂性需要进一步研究以调查PCOS患者甲状腺功能减退的患病率。
不适用。
