低25（羟）维生素D水平与多囊卵巢综合征中的自身免疫性甲状腺疾病相关。
Low 25 (OH) vitamin D levels are associated with autoimmune thyroid disease in polycystic ovary syndrome.
作者信息
Muscogiuri Giovanna, Palomba Stefano, Caggiano Mario, Tafuri Domenico, Colao Annamaria, Orio Francesco
机构信息
Department of Clinical Medicine and Surgery, "Federico II" University of Naples, via S. Pansini 5, 80131, Naples, Italy.
Department of Obstetrics and Gynecology, IRCCS, Arcispedale S. Maria Nuova of Reggio Emilia, Reggio Emilia, Italy.
出版信息
Endocrine. 2016 Aug;53(2):538-42. doi: 10.1007/s12020-015-0745-0. Epub 2015 Oct 3.
Low 25(OH) vitamin D levels have been associated with several autoimmune diseases and recently with autoimmune thyroid disease (AITD). The aim of the study was to investigate the association of AITD with 25(OH) vitamin D levels in women with polycystic ovary syndrome (PCOS). Fifty women with PCOS were consecutively enrolled and underwent routine health checkups, which included measurements of 25(OH) vitamin D, anti-thyroid peroxidase (TPO-Ab), anti-thyreoglobulin (TG-Ab) antibodies, FT3, FT4, and TSH. Selecting 50 nmol/L as cut-off point, low 25(OH) vitamin D levels were detected in 23 of 50 patients (46 %). AITD was diagnosed when TPO-Ab levels exceeding 80 U/ml and/or TG-Ab levels exceeding 70 U/ml. AITD was detected in 12 of 50 patients (24 %). The levels of 25(OH) vitamin D were significantly lower in women with PCOS and AITD when compared with women with PCOS and without AITD (p = 0.02). In women with AITD no correlation was found between 25(OH) vitamin D and TG-Ab (r = 0.48; p = 0.16), TPO-Ab (r = 0.43; p = 0.21), TSH (r = 0.38; p = 0.27), FT3 (r = -0.40; p = 0.25) and FT4 levels (r = -0.54; p = 0.10). These findings suggest that low levels of 25(OH) vitamin D were significantly associated with AITD in women with PCOS.
低25(OH)维生素D水平与多种自身免疫性疾病相关，最近还与自身免疫性甲状腺疾病（AITD）有关。本研究的目的是调查多囊卵巢综合征（PCOS）女性中AITD与25(OH)维生素D水平的关联。连续纳入50例PCOS女性并进行常规健康检查，包括检测25(OH)维生素D、抗甲状腺过氧化物酶（TPO-Ab）、抗甲状腺球蛋白（TG-Ab）抗体、FT3、FT4和TSH。选取50 nmol/L作为截断点，50例患者中有23例（46%）检测到低25(OH)维生素D水平。当TPO-Ab水平超过80 U/ml和/或TG-Ab水平超过70 U/ml时诊断为AITD。50例患者中有12例（24%）检测到AITD。与无AITD的PCOS女性相比，患有AITD的PCOS女性的25(OH)维生素D水平显著更低（p = 0.02）。在患有AITD的女性中，未发现25(OH)维生素D与TG-Ab（r = 0.48；p = 0.16）、TPO-Ab（r = 0.43；p = 0.21）、TSH（r = 0.38；p = 0.27）、FT3（r = -0.40；p = 0.25）和FT4水平（r = -0.54；p = 0.10）之间存在相关性。这些发现表明，低水平的25(OH)维生素D与PCOS女性的AITD显著相关。
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