血清抗-HBc阴性的乙肝表面抗原携带婴儿。

HBsAg carrier infants with serum anti-HBc negativity.

作者信息

Lee S D, Lo K J, Tsai Y T, Wu J C, Wu T C

机构信息

Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.

出版信息

Hepatology. 1989 Jan;9(1):102-4. doi: 10.1002/hep.1840090117.

DOI:10.1002/hep.1840090117

PMID:2521178

Abstract

A total of 128 HBsAg carrier infants born to HBeAg-positive HBsAg carrier mothers were tested for serum HBsAg, HBeAg, hepatitis B virus DNA and anti-HBc. Ninety-three of them had received hepatitis B vaccination. Anti-HBc had been found to be negative in sera of 12 infants who were HBsAg, HBeAg and hepatitis B virus DNA positive during the follow-up period of 3 to 5 years. Liver damage, as measured by serum ALT levels, was found to be normal among the 12 HBsAg carrier infants with serum anti-HBc negativity, whereas 39.7% of the 116 anti-HBc-positive HBsAg carrier infants had abnormal ALT levels during the follow-up period. Anti-HBe and anti-HBs also were not detected in sera of these anti-HBc-negative HBsAg carrier infants. Thus, HBsAg carrier infants with anti-HBc negativity probably result from immune incompetency of the hepatitis B virus antigens.

摘要

对128名母亲为HBeAg阳性的HBsAg携带者的婴儿进行了血清HBsAg、HBeAg、乙肝病毒DNA和抗-HBc检测。其中93名婴儿接受了乙肝疫苗接种。在3至5年的随访期内，12名婴儿的血清HBsAg、HBeAg和乙肝病毒DNA呈阳性，但抗-HBc呈阴性。在这12名抗-HBc阴性的HBsAg携带者婴儿中，血清ALT水平测定的肝损伤正常，而在116名抗-HBc阳性的HBsAg携带者婴儿中，39.7%在随访期内ALT水平异常。这些抗-HBc阴性的HBsAg携带者婴儿的血清中也未检测到抗-HBe和抗-HBs。因此，抗-HBc阴性的HBsAg携带者婴儿可能是由于乙肝病毒抗原的免疫无能所致。