Pongpipat D, Suvatte V, Assateerawatts A
Asian Pac J Allergy Immunol. 1985 Dec;3(2):191-3.
Perinatal transmission of hepatitis B virus (HBV) from asymptomatic HBsAg carrier mothers to their infants was studied in 78 mother-infant pairs by determination of HBsAg, HBeAg and anti-HBe both in the mothers and in their infants at regular intervals for those children up to the time when they reached at least one year of age. Twenty-five out of the 78 (32.1%) infants born to these mothers were HBsAg-positive 2-6 months after birth and they remained so throughout the observation period of at least one year or more. Perinatal HBV transmission occurred only in infants born to HBsAg carrier mothers who were HBeAg-positive (92.6%) but not in those born to HBsAg carrier mothers who had no detectable HBeAg. This study suggests that preventive measures against HBV transmission during the perinatal period should be taken only for infants born to HBsAg carrier mothers who are HBeAg-positive. In addition, the active immune response to HBV was studied in 75 non-HBsAg carrier infants born to HBsAg carrier mothers by determination of anti-HBs at one year of age or older. Forty-three of these infants were treated with HBIG at birth and 32 infants received no treatment. It was found that infants born to HBsAg carrier mothers who were HBeAg-positive had a better active immune response (84.2% positive for anti-HBs) than infants born to HBsAg carrier mothers who had no detectable HBeAg or anti-HBe (14.3% and 20.4% positive for anti-HBs respectively).
通过对78对母婴进行研究，定期检测母亲及其婴儿的乙肝表面抗原（HBsAg）、乙肝e抗原（HBeAg）和乙肝e抗体（抗-HBe），直至婴儿至少满1岁，以探讨无症状HBsAg携带者母亲向其婴儿的围产期乙肝病毒（HBV）传播情况。这些母亲所生的78名婴儿中，有25名（32.1%）在出生后2至6个月时HBsAg呈阳性，并且在至少1年或更长时间的观察期内一直保持阳性。围产期HBV传播仅发生在母亲为HBeAg阳性的HBsAg携带者所生的婴儿中（92.6%），而母亲HBsAg携带者且未检测到HBeAg的婴儿中未发生传播。本研究表明，围产期预防HBV传播的措施应仅针对母亲为HBeAg阳性的HBsAg携带者所生的婴儿。此外，通过检测75名母亲为HBsAg携带者的非HBsAg携带者婴儿1岁及以上时的乙肝表面抗体（抗-HBs），研究了其对HBV的主动免疫反应。其中43名婴儿在出生时接受了乙肝免疫球蛋白（HBIG）治疗，32名婴儿未接受治疗。结果发现，母亲为HBeAg阳性的HBsAg携带者所生的婴儿比母亲HBsAg携带者且未检测到HBeAg或抗-HBe的婴儿具有更好的主动免疫反应（抗-HBs阳性率分别为84.2%、14.3%和20.4%）。
