Uguccioni Ginevra, Pallanca Olivier, Golmard Jean-Louis, Leu-Semenescu Smaranda, Arnulf Isabelle
Sleep Disorder Unit, Pitié-Salpêtrière University Hospital, APHP, Paris, France; Brain Research Institute (CRICM-UPMC-Paris6; Inserm UMR_S 975; CNRS UMR 7225), Paris, France; Sorbonne Universites, UPMC Univ Paris 06, Paris, France.
J Sleep Res. 2015 Apr;24(2):197-205. doi: 10.1111/jsr.12219. Epub 2014 Sep 12.
In order to evaluate verbal memory consolidation during sleep in subjects experiencing sleepwalking or sleep terror, 19 patients experiencing sleepwalking/sleep terror and 19 controls performed two verbal memory tasks (16-word list from the Free and Cued Selective Reminding Test, and a 220- and 263-word modified story recall test) in the evening, followed by nocturnal video polysomnography (n = 29) and morning recall (night-time consolidation after 14 h, n = 38). The following morning, they were given a daytime learning task using the modified story recall test in reverse order, followed by an evening recall test after 9 h of wakefulness (daytime consolidation, n = 38). The patients experiencing sleepwalking/sleep terror exhibited more frequent awakenings during slow-wave sleep and longer wakefulness after sleep onset than the controls. Despite this reduction in sleep quality among sleepwalking/sleep terror patients, they improved their scores on the verbal tests the morning after sleep compared with the previous evening (+16 ± 33%) equally well as the controls (+2 ± 13%). The performance of both groups worsened during the daytime in the absence of sleep (-16 ± 15% for the sleepwalking/sleep terror group and -14 ± 11% for the control group). There was no significant correlation between the rate of memory consolidation and any of the sleep measures. Seven patients experiencing sleepwalking also sleep-talked during slow-wave sleep, but their sentences were unrelated to the tests or the list of words learned during the evening. In conclusion, the alteration of slow-wave sleep during sleepwalking/sleep terror does not noticeably impact on sleep-related verbal memory consolidation.
为了评估梦游或夜惊患者睡眠期间的言语记忆巩固情况，19名梦游/夜惊患者和19名对照者在晚上进行了两项言语记忆任务（自由和提示性选择性回忆测试中的16词列表，以及一个220词和263词的修改后的故事回忆测试），随后进行夜间视频多导睡眠图监测（n = 29）和早晨回忆测试（14小时后的夜间巩固，n = 38）。第二天早上，他们以相反顺序使用修改后的故事回忆测试进行白天学习任务，然后在清醒9小时后进行晚上回忆测试（白天巩固，n = 38）。与对照组相比，梦游/夜惊患者在慢波睡眠期间觉醒更频繁，入睡后清醒时间更长。尽管梦游/夜惊患者的睡眠质量有所下降，但与前一晚相比，他们在睡眠后第二天早上的言语测试成绩提高了（+16±33%），与对照组（+2±13%）相当。在没有睡眠的白天，两组的表现均变差（梦游/夜惊组为-16±15%，对照组为-14±11%）。记忆巩固率与任何睡眠指标之间均无显著相关性。7名梦游患者在慢波睡眠期间也说梦话，但他们的话语与测试或晚上学习的单词列表无关。总之，梦游/夜惊期间慢波睡眠的改变对与睡眠相关的言语记忆巩固没有明显影响。
