Department of Radiology, Research Institute of Radiological Science, Seoul, Korea.
Department of Biostatistics, Yonsei University College of Medicine, Seoul, Korea.
Ultrasonography. 2014 Oct;33(4):291-7. doi: 10.14366/usg.14028. Epub 2014 Aug 11.
To investigate the characteristics of papillary thyroid carcinoma (PTC) with cystic changes visible on ultrasonography (US).
This study included 553 PTCs in 553 patients between January 2003 and August 2004. One radiologist with 10 years of experience in thyroid imaging retrospectively reviewed the preoperative US images. Two different groups were formed according to two different reference points (group 1, 25%; group 2, 50%) of the cystic component. Patients between the groups were compared according to their clinicopathologic characteristics. Disease-free survival (DFS) was estimated. Cox's multivariate proportional hazards regression model was used to identify the effect of variable factors on the recurrence risk.
Fifty-six patients (10.1%) were confirmed to have tumor recurrence within the follow-up period. Thirty-five patients had regional metastasis, one had distant metastasis, eight had multiple site metastases, and 12 had biochemical recurrence. PTC patients with a ≤ 50% or PTC patients with a ≤ 25% cystic component did not have a statistically significant longer DFS than those with a >50% (hazard ratio [HR], 1.118; 95% confidence interval [CI], 0.255 to 4.910; P=0.883) or those with a >25% cystic component (HR, 0.569; 95% CI, 0.164 to 1.976; P=0.375), respectively. Moreover, independent predictors of recurrence were pathologic size, male gender, and lymph node metastasis, not a >50% or >25% cystic component.
The proportion of the cystic component in PTCs did not affect DFS.
探讨超声可见囊性改变的甲状腺乳头状癌（PTC）的特征。
本研究纳入了 2003 年 1 月至 2004 年 8 月间的 553 例 553 名 PTC 患者。一名具有 10 年甲状腺影像学经验的放射科医生回顾性地分析了术前超声图像。根据囊性成分的两个不同参考点（组 1，25%；组 2，50%）将患者分为两组。根据两组患者的临床病理特征进行比较。估计无病生存（DFS）。Cox 多变量比例风险回归模型用于确定变量因素对复发风险的影响。
56 例（10.1%）患者在随访期间被确诊为肿瘤复发。35 例患者发生区域转移，1 例发生远处转移，8 例发生多处转移，12 例发生生化复发。囊性成分≤50%或囊性成分≤25%的 PTC 患者与囊性成分>50%（风险比[HR]，1.118；95%置信区间[CI]，0.255 至 4.910；P=0.883）或囊性成分>25%的患者（HR，0.569；95% CI，0.164 至 1.976；P=0.375）相比，DFS 没有显著差异。此外，复发的独立预测因素是病理大小、男性和淋巴结转移，而不是囊性成分>50%或>25%。
PTC 中囊性成分的比例不影响 DFS。
