McMurray J J, Struthers A D
Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland.
Hypertension. 1989 Jan;13(1):9-14. doi: 10.1161/01.hyp.13.1.9.
The effects of atrial natriuretic factor (0.025 microgram/kg/min) on isoproterenol-(0.02 microgram/kg/min) and furosemide-(5 mg i.v. bolus) stimulated renin release were studied in seven salt-replete healthy volunteers. Isoproterenol or furosemide were given against a background infusion of 5% D-glucose (placebo day) or atrial natriuretic factor (experimental day). Atrial natriuretic factor abolished the rise in plasma renin activity caused by isoproterenol (p = 0.003) and significantly (p = 0.048) attenuated the rise in plasma renin activity after a bolus injection of furosemide. These results show that a pharmacological dose of atrial natriuretic factor inhibits stimulated renin release in humans. This attenuation is apparent with two heterogenous stimuli, which suggests a nonspecific effect.
在7名钠负荷正常的健康志愿者中，研究了心房利钠因子（0.025微克/千克/分钟）对异丙肾上腺素（0.02微克/千克/分钟）和速尿（静脉推注5毫克）刺激肾素释放的影响。异丙肾上腺素或速尿是在5%葡萄糖背景输注（安慰剂日）或心房利钠因子（实验日）的情况下给予的。心房利钠因子消除了异丙肾上腺素引起的血浆肾素活性升高（p = 0.003），并显著（p = 0.048）减弱了速尿静脉推注后血浆肾素活性的升高。这些结果表明，药理剂量的心房利钠因子可抑制人体中刺激的肾素释放。这种减弱在两种不同的刺激下都很明显，这表明存在非特异性效应。
