Lynch L, Berkowitz G S, Chitkara U, Wilkins I A, Mehalek K E, Berkowitz R L
Department of Obstetrics, Mount Sinai Medical Center, New York, New York.
Obstet Gynecol. 1989 Feb;73(2):267-70.
Several ultrasonographic signs have been described in second-trimester fetuses at high risk for Down syndrome. We examined these parameters in twin pregnancies in which one fetus was affected with Down syndrome and the other was normal. Biparietal diameter to femur length ratio was concordant (either normal or abnormal) in eight of nine sets of twins. Actual femur length to expected femur length ratio was concordant in seven of nine sets of twins. Nuchal fold thickening (6 mm or more) correctly identified five out of nine affected fetuses and was not present in any of the normal fetuses. In conclusion, neither ratio was helpful in differentiating the fetus with Down syndrome from its normal cotwin. A thickened nuchal fold was the most informative parameter examined.
已经描述了孕中期唐氏综合征高危胎儿的几种超声特征。我们在双胎妊娠中检查了这些参数，其中一个胎儿患有唐氏综合征而另一个正常。在9对双胞胎中，有8对的双顶径与股骨长度之比是一致的（要么正常要么异常）。实际股骨长度与预期股骨长度之比在9对双胞胎中有7对是一致的。颈部褶皱增厚（6毫米或更厚）正确识别出了9例受影响胎儿中的5例，且所有正常胎儿均未出现该情况。总之，这两个比例均无助于将患有唐氏综合征的胎儿与其正常的双胎区分开来。增厚的颈部褶皱是所检查的最具信息量的参数。
