Shah Y G, Eckl C J, Stinson S K, Woods J R
Department of Obstetrics and Gynecology, University of Rochester, Strong Memorial Hospital, New York.
Obstet Gynecol. 1990 Feb;75(2):186-8.
Previous published reports have shown that fetuses affected with Down syndrome have normal biparietal diameter (BPD), high BPD-to-femur length ratio, and shorter femur length and occipitofrontal diameter. A retrospective comparison of the BPD, occipitofrontal diameter, cephalic index, femur length, and BPD/femur length ratio was made between 17 fetuses with Down syndrome diagnosed prenatally by second-trimester amniocentesis and 17 matched controls. The gestational age at sonographic evaluation in the two groups ranged from 15-23 weeks. The results of this study show no significant differences in the BPD, occipitofrontal diameter, cephalic index, femur length, and BPD/femur length ratio in the Down syndrome group when compared with controls. The sensitivity of BPD/femur length ratio as a screening technique for Down syndrome in this study was 18%, with a specificity of 94%. This sonographic method does not appear to be a useful screening parameter for Down syndrome.
先前发表的报告显示，患有唐氏综合征的胎儿双顶径（BPD）正常，双顶径与股骨长度比值较高，股骨长度和枕额径较短。对17例经孕中期羊水穿刺产前诊断为唐氏综合征的胎儿与17例匹配的对照组胎儿的双顶径、枕额径、头指数、股骨长度及双顶径/股骨长度比值进行了回顾性比较。两组超声评估时的孕周为15 - 23周。本研究结果显示，与对照组相比，唐氏综合征组在双顶径、枕额径、头指数、股骨长度及双顶径/股骨长度比值方面无显著差异。本研究中，双顶径/股骨长度比值作为唐氏综合征筛查技术的敏感性为18%，特异性为94%。这种超声方法似乎不是唐氏综合征有用的筛查参数。
