Murphy William L
Departments of Biomedical Engineering, Pharmacology, Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI, 53706, USA.
Soft Matter. 2011 Apr;7(8):3679-3688. doi: 10.1039/C0SM01351J.
Traditional dynamic hydrogels have been designed to respond to changes in physicochemical inputs, such as pH and temperature, for a wide range of biomedical applications. An emerging strategy that may allow for more specific "bio-responsiveness" in synthetic hydrogels involves mimicking or exploiting nature's dynamic proteins. Hundreds of proteins are known to undergo pronounced conformational changes in response to specific biochemical triggers, and these responses represent a potentially attractive toolkit for design of dynamic materials. This "emerging area" review focuses on the use of protein motions as a new paradigm for design of dynamic hydrogels. In particular, the review emphasizes early examples of dynamic hydrogels that harness well-known protein motions. These examples then serve as templates to discuss challenges and suggest emerging directions in the field. Successful early examples of this approach, coupled with the fundamental properties of nature's protein motions, suggest that protein-based materials may ultimately achieve specific, multiplexed responses to a range of biochemical triggers. Applications of this new class of materials include drug delivery, biosensing, bioactuation, and tissue engineering.
传统的动态水凝胶已被设计用于响应物理化学输入（如pH值和温度）的变化，以用于广泛的生物医学应用。一种可能使合成水凝胶具有更特定“生物响应性”的新兴策略涉及模仿或利用自然界的动态蛋白质。已知数百种蛋白质会因特定的生化触发因素而发生明显的构象变化，这些响应代表了一种潜在的、有吸引力的动态材料设计工具包。这篇“新兴领域”综述聚焦于将蛋白质运动用作动态水凝胶设计的新范式。特别地，该综述强调了利用著名蛋白质运动的动态水凝胶的早期实例。这些实例随后作为模板，用于讨论该领域的挑战并提出新兴方向。这种方法的成功早期实例，再加上自然界蛋白质运动的基本特性，表明基于蛋白质的材料最终可能实现对一系列生化触发因素的特定、多重响应。这类新材料的应用包括药物递送、生物传感、生物驱动和组织工程。
