综合重症监护病房的抗生素处方及费用模式
Antibiotic prescription and cost patterns in a general intensive care unit.
作者信息
Krivoy Norberto, El-Ahal Wissam Abed, Bar-Lavie Yaron, Haddad Salim
机构信息
Division of Medicine, Clinical Pharmacology Unit. Rambam Medical Center and B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology. Haifa ( Israel ).
Rambam Medical Center and B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology. Haifa ( Israel ).
出版信息
Pharm Pract (Granada). 2007;5(2):67-73. doi: 10.4321/s1886-36552007000200003.
UNLABELLED
Antibiotic prescription habits, cost pattern, and the prospective intervention in an Intensive Care Unit were analyzed.
METHODS
Data on antibiotic utilization and costs were collected prospectively from individual electronic charts from August 2003 to January 2004, and retrospectively from August to December 2002.
RESULTS
A total of 180 and 107 patients were surveyed in 2002 and 2003. In 2002, Piperacillin-Tazobactam (13.8%) and Imipenem/Cilastin (11.2%) were the most prescribed medications; while, in 2003, Vancomycin (12.6%) and Imipenem/Cilastin (11.3%) were prescribed, respectively. Total defined daily dose (DDD) and Drug Utilization 90% (DU90%) index for 2002 and 2003 were 2031.15 and 2325.90 DDDs (p>0.1) and 1777.57 and 2079.61 DU90%, respectively (p>0.1). The Median Total Cost /100 admission days (CI 95%) were NIS13,310 (11,110;18,420) and NIS13,860 (6,710;18,020) (p=0.66), respectively.
CONCLUSIONS
Interventional programs should focus on promoting infectious control with rational antibiotic prescription aimed at minimizing the future emergence of bacterial resistance and futile expenses.
未标注
分析了重症监护病房的抗生素处方习惯、成本模式及前瞻性干预措施。
方法
前瞻性收集2003年8月至2004年1月来自个体电子病历的抗生素使用及成本数据，并回顾性收集2002年8月至12月的数据。
结果
2002年和2003年分别共调查了180例和107例患者。2002年，哌拉西林-他唑巴坦（13.8%）和亚胺培南/西司他丁（11.2%）是最常开具的药物；而在2003年，分别开具了万古霉素（12.6%）和亚胺培南/西司他丁（11.3%）。2002年和2003年的总限定日剂量（DDD）和药物利用90%（DU90%）指数分别为2031.15和2325.90 DDDs（p>0.1）以及1777.57和2079.61 DU90%（p>0.1）。每100个住院日的总费用中位数（95%置信区间）分别为13310新谢克尔（11110；18420）和13860新谢克尔（6710；18020）（p=0.66）。
结论
干预项目应侧重于通过合理使用抗生素促进感染控制，以尽量减少未来细菌耐药性的出现和不必要的费用。
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