犬类胰岛素的鼻腔吸收。
Nasal absorption of insulin in dogs.
作者信息
Harai S, Ikenaga T, Matsuzawa T
出版信息
Diabetes. 1978 Mar;27(3):296-9. doi: 10.2337/diab.27.3.296.
PMID:25215
Abstract
The intranasal application of an insulin solution in dogs resulted in the rise of plasma immunoreactive insulin and in dose-dependent hypoglycemia. The absorption of insulin from this site was found to be enhanced when insulin was dissolved in an acid medium. In addition, when an insulin preparation with some surfactant was used, the effectiveness of nasally administered insulin was 25 to 30 per cent of that achieved with intravenously administered insulin.
摘要
在犬类中鼻内应用胰岛素溶液会导致血浆免疫反应性胰岛素升高以及剂量依赖性低血糖。当胰岛素溶解于酸性介质中时，发现从该部位的胰岛素吸收会增强。此外，当使用含有某种表面活性剂的胰岛素制剂时，经鼻给药胰岛素的有效性为静脉给药胰岛素的25%至30%。
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