新型见解：高迁移率族蛋白 B1 介导的脓毒症细胞免疫反应：系统综述。
Novel insights for high mobility group box 1 protein-mediated cellular immune response in sepsis: A systemic review.
机构信息
Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese People's Liberation Army General Hospital, Beijing 100048, China.
出版信息
World J Emerg Med. 2012;3(3):165-71. doi: 10.5847/wjem.j.issn.1920-8642.2012.03.001.
BACKGROUND
High mobility group box 1 protein (HMGB1) is a highly conserved, ubiquitous protein in the nuclei and cytoplasm of nearly all cell types. HMGB1 is secreted into the extracellular milieu and acts as a proinfl ammatory cytokine. In this article we reviewed briefl y the cellular immune response mediated by HMGB1 in infl ammation and sepsis.
METHODS
This systemic review is mainly based on our own work and other related reports.
RESULTS
HMGB1 can actively affect the immune functions of many types of cells including T lymphocytes, regulatory T cells (Tregs), dendritic cells (DCs), macrophages, and natural killer cells (NK cells). Various cellular responses can be mediated by HMGB1 which binds to cell-surface receptors [e.g., the receptor for advanced glycation end products (RAGE), Toll-like receptor (TLR)2, and TLR4]. Anti-HMGB1 treatment, such as anti-HMGB1 polyclonal or monoclonal antibodies, inhibitors (e.g., ethyl pyruvate) and antagonists (e.g., A box), can protect against sepsis lethality and give a wider window for the treatment opportunity.
CONCLUSION
HMGB1 is an attractive target for the development of new therapeutic strategies in the treatment of patients with septic complications.
背景
高迁移率族蛋白 B1（HMGB1）是一种高度保守、普遍存在于几乎所有细胞类型的核和细胞质中的蛋白质。HMGB1 被分泌到细胞外环境中，并作为一种促炎细胞因子发挥作用。本文简要综述了 HMGB1 在炎症和脓毒症中介导的细胞免疫反应。
方法
本综述主要基于我们自己的工作和其他相关报道。
结果
HMGB1 可以主动影响包括 T 淋巴细胞、调节性 T 细胞（Tregs）、树突状细胞（DCs）、巨噬细胞和自然杀伤细胞（NK 细胞）在内的多种类型细胞的免疫功能。HMGB1 可以通过与细胞表面受体（如晚期糖基化终产物受体（RAGE）、Toll 样受体（TLR）2 和 TLR4）结合来介导各种细胞反应。抗-HMGB1 治疗，如抗-HMGB1 多克隆或单克隆抗体、抑制剂（如丙酮酸乙酯）和拮抗剂（如 A 盒），可以防止脓毒症的致死性，并为治疗提供更宽的窗口。
结论
HMGB1 是开发治疗脓毒症并发症患者的新治疗策略的有吸引力的靶点。
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