Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology, 280 South Chongqing Road, Shanghai 200025, China.
J Immunol Res. 2014;2014:698192. doi: 10.1155/2014/698192. Epub 2014 Aug 21.
Rheumatoid arthritis (RA) is a common autoimmune disease with unknown etiology and pathogenesis. Although major therapeutic advances have been made in recent years, there is no cure for the disease. Current medications mainly reduce inflammation in order to relieve pain and slow joint damage, but many have potentially serious side effects. Therefore, to find specific biomarkers will benefit both RA patients to find relief from the disease and physicians to monitor the disease development. A number of biomarkers have been discovered and used clinically, and others are still under investigation. The autoantibodies, which are widely used in diagnosis and prognosis, novel biomarkers, which reflect clinical disease activity, and newly found biomarkers and pathogenic-related cytokines are discussed in this review.
类风湿关节炎（RA）是一种常见的自身免疫性疾病，病因和发病机制尚不清楚。尽管近年来在治疗方面取得了重大进展，但该病仍无法治愈。目前的药物治疗主要是为了减轻炎症以缓解疼痛和减缓关节损伤，但许多药物都有潜在的严重副作用。因此，寻找特定的生物标志物将使 RA 患者受益，使他们能够缓解疾病，也使医生能够监测疾病的发展。已经发现了许多生物标志物并在临床上使用，还有一些正在研究中。本文综述了广泛用于诊断和预后的自身抗体、反映临床疾病活动的新型生物标志物以及新发现的与发病机制相关的生物标志物和细胞因子。
