The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, 214041, China,
Clin Rheumatol. 2013 Oct;32(10):1425-8. doi: 10.1007/s10067-013-2341-0. Epub 2013 Jul 23.
Interleukin (IL)-27 is a novel member of the IL-6/IL-12 family of cytokines with a broad range of pro- and anti-inflammatory properties. Recently, accumulating evidence has shown that IL-27 can play either a pathogenic or a protective role in animal models of inflammatory arthritis, depending upon the model and underlying pathogenic mechanisms. As to human system, elevated expression of IL-27 has clearly been detected in the synovial membranes and fluid from patients with rheumatoid arthritis (RA). Moreover, stimulation of IL-27 receptor with IL-27 of fibroblast-like synoviocytes from RA had a suppressive effect on the production of proinflammatory cytokines in vitro. All these findings suggest that IL-27 may have promise as a potential therapeutic target for RA. In this review, we will discuss the biological features of IL-27 and summarize recent advances on both pathogenic and protective roles of IL-27 in RA.
白细胞介素 (IL)-27 是一种新型的白细胞介素 6/12 细胞因子家族成员，具有广泛的促炎和抗炎特性。最近，越来越多的证据表明，IL-27 在炎症性关节炎的动物模型中可以发挥致病或保护作用，具体取决于模型和潜在的发病机制。在人类系统中，在类风湿关节炎 (RA) 患者的滑膜膜和滑液中明显检测到 IL-27 的高表达。此外，体外用 IL-27 刺激 RA 成纤维样滑膜细胞的 IL-27 受体对促炎细胞因子的产生具有抑制作用。所有这些发现表明，IL-27 可能有希望成为 RA 的潜在治疗靶点。在这篇综述中，我们将讨论 IL-27 的生物学特征，并总结最近关于 IL-27 在 RA 中的致病和保护作用的进展。
