富锌酵母在大鼠体内的药代动力学和生物分布

Pharmacokinetics and biodistribution of zinc-enriched yeast in rats.

作者信息

Zhang Shuangqing, Zhang Yan, Peng Ning, Zhang Haibo, Yao Juan, Li Zhihong, Liu Liegang

机构信息

Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, China ; Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, China.

出版信息

ScientificWorldJournal. 2014;2014:217142. doi: 10.1155/2014/217142. Epub 2014 Aug 17.

DOI:10.1155/2014/217142

PMID:25215316

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4151581/

Abstract

Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats. ZnY or ZnSO4 were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO4, respectively. Both ZnY and ZnSO4 were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO4, the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO4.

摘要

富锌酵母（ZnY）和硫酸锌（ZnSO4）被认为是目前可用的锌（Zn）补充剂。本研究的目的是比较和评估ZnY和ZnSO4在大鼠体内的药代动力学和生物分布。以4 mg Zn/kg的单剂量给大鼠口服ZnY或ZnSO4，并使用电感耦合等离子体发射光谱法测定血浆和各种组织中的锌水平。ZnY和ZnSO4的最大血浆浓度值分别为3.87和2.81μg/mL。ZnY和ZnSO4均被缓慢消除，半衰期超过7小时，并且在所有组织中骨骼的锌水平最高。与ZnSO4相比，ZnY的相对生物利用度为138.4%，表明ZnY具有比ZnSO4显著更高的生物利用度。