Kropiunigg U, Hamilton G, Roth E, Simmel A
Psychother Psychosom Med Psychol. 1989 Jan;39(1):18-25.
Measurements were made of cellular immune system parameters in a group of healthy medical students. On the basis of psychosocial stress encountered during a five-day topic-centered self-awareness course, we investigated modulation in immunity in relation to personality characteristics. 6 days before the beginning of the seminar personality profiles were drawn and blood samples taken. Further immunological measurements were made on day four of the seminar and three weeks after its conclusion. On the fourth day of the seminar we observed throughout the group higher lymphocyte and suppressor/cytotoxic T lymphocyte counts in comparison with counts one week earlier, and likewise a heightened responsiveness to PHA- and IL-2 stimulation. The T lymphocyte counts had dropped. In subjects with a higher need for succorance/nurturance, the depression of the immune system was manifested in a drop in the helper/inducer T lymphocyte counts, and in the more achievement- and order-oriented subjects in a downregulation as observed by higher suppressor/cytotoxic T lymphocyte counts. Our results show that under psychosocial stress, healthy people experience on the one hand an activation of the immune system, and on the other hand an immunodepression bearing a specific relation to personality characteristics.
对一组健康医学生的细胞免疫系统参数进行了测量。基于在为期五天的以主题为中心的自我认知课程中所遇到的心理社会压力，我们研究了与人格特征相关的免疫调节情况。在研讨会开始前6天绘制人格剖面图并采集血样。在研讨会的第四天及其结束三周后进行了进一步的免疫学测量。在研讨会的第四天，我们观察到与一周前相比，整个小组的淋巴细胞以及抑制性/细胞毒性T淋巴细胞计数更高，同样对PHA和IL-2刺激的反应性增强。T淋巴细胞计数有所下降。在更需要帮助/呵护的受试者中，免疫系统的抑制表现为辅助性/诱导性T淋巴细胞计数下降，而在更注重成就和秩序导向的受试者中，如通过更高的抑制性/细胞毒性T淋巴细胞计数所观察到的那样，表现为下调。我们的结果表明，在心理社会压力下，健康人一方面会经历免疫系统的激活，另一方面会经历与人格特征具有特定关系的免疫抑制。
