Lellé R J, Toboll G, Kaulhausen H, Heidenreich W
Zentralbl Gynakol. 1986;108(15):919-24.
Lymphocyte subsets from peripheral venous blood of 11 patients with preeclampsia were enumerated by monoclonal antibodies and compared to the values of 10 normal term pregnant women. All women were in their last trimester of pregnancy. The number of B and T cells was similar in both groups. In the preeclampsia group, more helper T cells could be shown, whereas the number of suppressor T cells was reduced. Thus, the helper/suppressor ratio was increased from 2.01 in normal pregnancies to 3.97 in preeclamptic patients. In two patients with a true-positive angiotensin stress test similar changes as in preeclampsia could be seen. In only one out of five patients with preeclampsia the helper/suppressor ratio returned to normal values four to five weeks after delivery.
采用单克隆抗体对11例先兆子痫患者外周静脉血中的淋巴细胞亚群进行计数，并与10例正常足月孕妇的值进行比较。所有女性均处于妊娠晚期。两组的B细胞和T细胞数量相似。先兆子痫组显示辅助性T细胞较多，而抑制性T细胞数量减少。因此，辅助性/抑制性T细胞比值从正常妊娠时的2.01增加到先兆子痫患者的3.97。在2例血管紧张素应激试验呈真阳性的患者中，可见到与先兆子痫类似的变化。在5例先兆子痫患者中，只有1例在产后4至5周辅助性/抑制性T细胞比值恢复到正常水平。
