Kleinjan Marloes, Rozing Mayke, Engels Rutger C M E, Verhagen Maaike
Radboud University Nijmegen.
Dev Psychopathol. 2015 Aug;27(3):915-25. doi: 10.1017/S0954579414000911. Epub 2014 Sep 12.
Alcohol use and depressive feelings are often related among early adolescents. However, the nature and underlying mechanisms of this association are not yet clear. The aim of this study was to investigate the co-development of alcohol use and depressive feelings over time and to examine the effects of the mu-opioid receptor (OPRM1) A118G genotype on such co-development. Data from a five-wave longitudinal, genetically informed survey study, with intervals of 4 months among a group of 739 normative early adolescents (12-13 years of age at baseline), were analyzed using a dual latent growth curve approach. OPRM1 status was evaluated from saliva-derived DNA samples. The results indicated a positive association between alcohol use and depressive feelings both at the initial levels and over time, indicating co-development in early adolescence. Compared to OPRM1 118G carriers, homozygous 118A carriers showed a greater increase in frequency of alcohol use and higher levels of depressive feelings over time. Evidence for co-development was only found within the group of homozygous 118A carriers, whereas in OPRM1 118G carriers the development of alcohol use and depressive feelings over time were not significantly associated. These results highlight the potential of OPRM1 as a common etiological factor for the development of alcohol use and depressive feelings in early adolescence.
在青少年早期，饮酒与抑郁情绪往往相关。然而，这种关联的本质和潜在机制尚不清楚。本研究的目的是调查饮酒与抑郁情绪随时间的共同发展情况，并检验μ-阿片受体（OPRM1）A118G基因型对这种共同发展的影响。使用双潜变量增长曲线方法分析了一项五波纵向、基于基因信息的调查研究的数据，该研究在一组739名正常青少年早期（基线时年龄为12 - 13岁）中进行，每4个月进行一次调查。通过唾液来源的DNA样本评估OPRM1状态。结果表明，在初始水平以及随时间推移，饮酒与抑郁情绪之间均呈正相关，表明在青少年早期存在共同发展的情况。与OPRM1 118G携带者相比，纯合118A携带者随着时间推移饮酒频率增加幅度更大，抑郁情绪水平更高。仅在纯合118A携带者组中发现了共同发展的证据，而在OPRM1 118G携带者中，饮酒与抑郁情绪随时间的发展没有显著关联。这些结果突出了OPRM1作为青少年早期饮酒和抑郁情绪发展的一个共同病因因素的潜力。
