Department of Psychology, Queens College and The Graduate Center, City University of New York, Flushing, New York; Department of Epidemiology, Mailman School of Public Health, New York, New York.
Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, New York.
Ann Allergy Asthma Immunol. 2014 Nov;113(5):565-70. doi: 10.1016/j.anai.2014.08.003. Epub 2014 Sep 10.
Several cross-sectional studies have found an association between respiratory disease and increased mood or anxiety disorders among adults. Little is known about the nature of these associations over time or the role of potential confounders in these links.
To investigate the association between respiratory disease and incident and persistent depression or anxiety disorders 10 years later and to examine potential pathways of these associations.
Data were drawn from the Midlife Development in the United States survey, a representative sample of adults in the United States ages 18 to 74 years. Participants (N = 2,101) were interviewed on a range of health domains at baseline at wave 1 (1994) and again at wave 2 (2005).
Respiratory disease was associated with increased odds of depression and anxiety disorders cross-sectionally at both time points. Respiratory disease at wave 1 was not associated with incident depression or anxiety disorders at wave 2. Respiratory disease at wave 1 was associated with increased odds of persistent depression or anxiety disorders 10 years later among those with depression or anxiety disorders at wave 1. Associations were not explained by differences in demographic characteristics, secondhand smoke exposure, cigarette smoking, or history of exposure to childhood maltreatment.
Findings shed new light on the association between respiratory disease and depression or anxiety disorders. Individuals with respiratory disease appear to have higher prevalence of concurrent depression or anxiety disorders and persistent depression or anxiety disorders compared with those without respiratory disease. However, a history of respiratory disease does not appear to confer increased risk of new onset of depression or anxiety disorders.
几项横断面研究发现，成年人的呼吸疾病与情绪或焦虑障碍的增加有关。关于这些关联随时间的性质或这些关联中潜在混杂因素的作用知之甚少。
调查呼吸疾病与 10 年后新发和持续抑郁或焦虑障碍之间的关联，并探讨这些关联的潜在途径。
数据来自美国中年发展调查，这是美国 18 至 74 岁成年人的代表性样本。参与者（N=2101）在基线时（第 1 波，1994 年）和第 2 波（2005 年）接受了一系列健康领域的访谈。
呼吸疾病与两个时间点的抑郁和焦虑障碍的横断面关联增加有关。第 1 波的呼吸疾病与第 2 波的新发抑郁或焦虑障碍无关。第 1 波的呼吸疾病与第 1 波时患有抑郁或焦虑障碍的人群中持续抑郁或焦虑障碍的几率增加有关。关联不能用人口统计学特征、二手烟暴露、吸烟或童年期受虐待的暴露史的差异来解释。
研究结果为呼吸疾病与抑郁或焦虑障碍之间的关联提供了新的认识。与没有呼吸疾病的人相比，患有呼吸疾病的个体似乎具有更高的并发抑郁或焦虑障碍和持续抑郁或焦虑障碍的患病率。然而，呼吸疾病的病史似乎不会增加新发抑郁或焦虑障碍的风险。
