Jiang-Hua Qiao, De-Chuang Jiao, Zhen-Duo Lu, Shu-de Cui, Zhenzhen Liu
Breast Cancer Center, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, 45008, China.
Tumour Biol. 2014 Dec;35(12):11895-901. doi: 10.1007/s13277-014-2456-1. Epub 2014 Sep 13.
We assessed the association between dietary intake of folate and the MTHFR genotype with breast cancer in a Chinese population, with additional analysis of the interactions of gene polymorphisms and dietary intake of folate, vitamin B6, and vitamin B12. A case-control study was performed, and 535 patients with newly diagnosed breast cancer and 673 controls were enrolled into this study. The MTHFR 667TT genotype (odds ratio (OR) = 1.82, 95 % confidence interval (CI) = 1.24-2.97) and T allele (OR 0= 1.48, 95 % CI = 1.15-1.78) were correlated with a moderately significant increased risk of breast cancer when compared with the CC genotype. Individuals carrying the MTR 2756GG genotype (OR = 1.66, 95 % CI = 1.16-2.56) and G allele (OR = 1.42, 95 % CI = 1.26-1.81) had a higher risk of breast cancer when compared with subjects with the AA genotype. The MTHFR 667 T allele and MTR 2756 G allele were associated with a higher risk of breast cancer in individuals with low folate intake, vitamin B6, and vitamin B12, but the association disappeared among subjects with moderate and high intake of folate, vitamin B6, and vitamin B12. This case-control study found that the MTHFR C677T and MTR A2756G polymorphisms are associated with risk of breast cancer, and folate, vitamin B6, and vitamin B12 intakes influence these associations.
我们评估了中国人群中叶酸的膳食摄入量与MTHFR基因分型和乳腺癌之间的关联，并对基因多态性与叶酸、维生素B6和维生素B12的膳食摄入量之间的相互作用进行了额外分析。开展了一项病例对照研究，共纳入535例新诊断的乳腺癌患者和673例对照。与CC基因型相比，MTHFR 667TT基因型（比值比（OR）=1.82，95%置信区间（CI）=1.24 - 2.97）和T等位基因（OR=1.48，95%CI=1.15 - 1.78）与乳腺癌风险中度显著增加相关。携带MTR 2756GG基因型（OR=1.66，95%CI=1.16 - 2.56）和G等位基因（OR=1.42，95%CI=1.26 - 1.81）的个体与AA基因型个体相比，患乳腺癌的风险更高。MTHFR 667 T等位基因和MTR 2756 G等位基因与叶酸、维生素B6和维生素B12摄入量低的个体患乳腺癌的风险较高有关，但在叶酸、维生素B6和维生素B12摄入量中等和高的个体中，这种关联消失。这项病例对照研究发现，MTHFR C677T和MTR A2756G多态性与乳腺癌风险相关，且叶酸、维生素B6和维生素B12的摄入量会影响这些关联。
