Tio Martin, Andrici Juliana, Eslick Guy D
The Whiteley-Martin Research Centre, The Discipline of Surgery, Sydney Medical School, The University of Sydney, Nepean Hospital, Level 5, South Block, Penrith, NSW, Australia.
Breast Cancer Res Treat. 2014 Jun;145(2):513-24. doi: 10.1007/s10549-014-2969-8. Epub 2014 Apr 29.
There is conflicting epidemiological evidence on the role of folate and breast cancer risk. We conducted a systematic review and quantitative meta-analysis of folate intake and folate blood levels and the risk of breast cancer. Four electronic databases (Medline, PubMed, Embase, and Current Contents Connect) were searched to April 11, 2014, with no language restrictions for observational studies that measured folate intake or blood levels and the risk of breast cancer. The meta-analysis of dietary folate intake comprising 36 studies with 34,602 cases, and a total sample size of 608,265 showed a decreased risk of breast cancer, with an odds ratio (OR) of 0.84 [95 % confidence interval (CI) 0.77-0.91]. When stratified by menopausal status and by study design, none of the meta-analyses of prospective studies showed any statistically significant decrease in the risk of breast cancer. The meta-analysis of total folate showed no statistically significant association with breast cancer OR of 0.98 (95 % CI 0.91-1.07). There was no significant association between either dietary or total folate intake and breast cancer when stratified by hormonal receptor status. The meta-analysis of blood folate levels found no significant association with the risk of breast cancer, with an OR of 0.86 (95 % CI 0.60-1.25). Breast cancer does not appear to be associated with folate intake, and this did not vary by menopausal status or hormonal receptor status. Folate blood levels also do not appear to be associated with breast cancer risk.
关于叶酸与乳腺癌风险之间的关系，流行病学证据存在矛盾。我们对叶酸摄入量、血液叶酸水平与乳腺癌风险进行了系统综述和定量荟萃分析。检索了四个电子数据库（Medline、PubMed、Embase和Current Contents Connect）至2014年4月11日的数据，纳入了测量叶酸摄入量或血液水平以及乳腺癌风险的观察性研究，无语言限制。对36项研究（共34,602例病例，总样本量608,265）进行的膳食叶酸摄入量荟萃分析显示，乳腺癌风险降低，比值比（OR）为0.84 [95%置信区间（CI）0.77 - 0.91]。按绝经状态和研究设计分层后，前瞻性研究的荟萃分析均未显示乳腺癌风险有任何统计学上的显著降低。总叶酸的荟萃分析显示与乳腺癌无统计学显著关联，OR为0.98（95% CI 0.91 - 1.07）。按激素受体状态分层时，膳食叶酸摄入量或总叶酸摄入量与乳腺癌之间均无显著关联。血液叶酸水平的荟萃分析未发现与乳腺癌风险有显著关联，OR为0.86（95% CI 0.60 - 1.25）。乳腺癌似乎与叶酸摄入量无关，且不受绝经状态或激素受体状态的影响。血液叶酸水平似乎也与乳腺癌风险无关。
